Nilüfer ZORLUTUNA KAYMAK, Gizem DOĞAN GÖKÇE, Mehmet Engin TEZCAN, Serap DEMİR TEKOL

Hastanede yatan yeni Coronavirus 2019 hastalarının gözyaşı örneklerinde Severe Acute Respiratory Syndrome Coronavirus-2 RNA’larının değerlendirilmesi

Amaç: Yeni Coronavirus 2019 hastalarının gözyaşlarında Severe Acute Respiratory Syndrome Coronavirus-2 RNA’sının varlığını tespit etmeyi amaçladık. Gereç ve Yöntem: Bu prospektif çalışma Sağlık Bilimleri Üniversitesi Kartal Dr. Lütfi Kırdar Şehir Hastanesi’nde 13-21 Mayıs 2020 tarihleri arasında gerçekleştirildi. Real-time polimeraz zincir reaksiyonu testi için yeni Coronavirus 2019 hastalığı olan 15 hastanın nazofarengeal ve gözyaşı örnekleri alındı. Oküler ve sistemik belirti ve bulgular, göğüs bilgisayarlı tomografi taramaları ve tedavi için kullanılan ilaçların yanı sıra laboratuvar testlerinin sonuçları kaydedildi. Bulgular: Onbeş hastanın dokuzu (60%) erkek, altısı (40%) kadındı. Hastaların ortalama yaşı 53.86±20.20 (21-89) idi. Dokuz hastanın (60%) nazofarengeal örneklerinde yeni Coronavirus 2019 hastalığı için real-time polimeraz zincir reaksiyon testi pozitifti. Hiçbir hastanın gözyaşı örneğinde Severe Acute Respiratory Syndrome Coronavirus-2 real-time polimeraz zincir reaksiyon testi pozitif değildi. Onbeş hastanın sadece ikisinde bilateral konjonktivit mevcuttu. Bu iki hastanın nazofarengeal örneklerinde Severe Acute Respiratory Syndrome Coronavirus-2 real-time polimeraz zincir reaksiyon testinin sonucu pozitifti. Sonuç: Bu çalışmada oküler belirti ve bulgusu olsun ya da olmasın yeni Coronavirus 2019 hastalarının gözyaşı örneklerinde Severe Acute Respiratory Syndrome Coronavirus-2 RNA tespit edilememiştir.

Hastanede yatan yeni Coronavirus 2019 hastalarının gözyaşı örneklerinde Severe Acute Respiratory Syndrome Coronavirus-2 RNA’larının değerlendirilmesi

Aim: We aimed to detect the presence of Severe Acute Respiratory Syndrome Coronavirus-2 RNA in the tears of patients with confirmed novel Coronavirus disease 2019. Materials and Methods: This prospective study was performed at Health Science University Kartal Dr. Lutfi Kırdar City Hospital between 13-21 May 2020. Nasopharyngeal and tear samples of 15 patients with novel Coronavirus disease 2019 was performed for real-time polymerase chain reaction assay. Ocular and systemic signs and symptoms, chest computed tomographic scans, and results of laboratory blood tests as well as the drugs used for the treatment were noted and analyzed. Results: Of the 15 patients nine (60%) were male and six (40%) were female. Mean age of the patients was 53.86±20.20 (21-89) years. Among them nine patients (60%) were positive for novel coronavirus disease 2019 on real-time polymerase chain reaction from nasopharyngeal specimens. None of the patients was positive for real-time polymerase chain reaction for Severe Acute Respiratory Syndrome Coronavirus-2 in tear specimens. Only two of 15 patients had bilateral conjunctivitis. These two patients had positive results for Severe Acute Respiratory Syndrome Coronavirus-2 on real-time polymerase chain reaction from nasopharyngeal swabs. Conclusion: In this study Severe Acute Respiratory Syndrome Coronavirus-2 RNA could not be detected in the tear samples of the patients with confirmed novel Coronavirus disease 2019 with or without ocular symptoms and signs.

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