The Relationship Between Calcium Metabolism Parameters

Blood calcium is under very tight control in a narrow range of 8.5-10.5 mg/dl. We aimed to investigate the factors that contributed to this control. 464 females and 254 males aged 16-96 years were examined retrospectively. PTH, 25OH vitamin D, Ca, Mg, P and spot urine calcium, creatinine levels were examined. The rates were as follow; hypercalcemia 5.6%, primary hyperparathyroidism 10.4%, secondary hyperparathyroidism 40.8%, tertiary hyperparathyroidism 17.5%, normal PTH hypercalcemia 1.25%, hypocalcemia 13.5%, hypoparathyroidism 3.7%, hypovitaminosis D 77.6%, hypophosphatemia 6.4%, hyperphosphatemia 17.5%, hypomagnesemia 17.5%, hypermagnesemia 10.4%. Severe vitamin D deficiency was found as 37% (n= 172) in females and 20% (n= 53) in males (p

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1.Hancı V, Özbilgin Ş. Kalsiyum Dengesi Bozuklukları: Hipokalsemi-Hiperkalsemi; Yoğun Bakım Dergisi 2018; 12: 43-58.

2. Moe SM. Disorders involving calcium, phosphorus, and magnesium. Prim Care 2008; 35: 215-237.

3. Zaloga GP. Hypocalcemia in critically ill patients. Crit Care Med 1992; 20: 251-262.

4. Zivin JR, Gooley T, Zager RA, Ryan MJ. Hypocalcemia: A pervasive metabolic abnormality in the critically ill. Am J Kidney Dis 2001; 37: 689- 698.

5. Carine GhassanRicha, Ali Ihsan Issa, Akram Salim Echtay and Mohamad Souheil El Rawas. CaseReport Idiopathic Hypoparathyroidism and Severe Hypocalcemia in Pregnancy. Hindawi Case Reports in Endocrinology Volume 2018, Article ID 8316017, 4 pages https://doi.org/10.1155/2018/8316017

6. Gois PHF, Ferreira D, Olenski S, Seguro A.C. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients 2017; 9: 651.

7. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos. Int 2009; 20: 1807-1820.

8. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81: 353-373.

9. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Eng J Med 1998; 338: 773.

10. Jennifer Ford, Ana Hategan, James A. Bourgeois, Daniel K. Tisi. Hypovitaminosis D: A Contributor to Psychiatric Disorders in Elderly? Canadian geriatric journal 2012; 15: No3.

11. Murray J. Favus, David A. Bushinsky, and Jacob Lemann Jr. Regulation of Calcium, Magnesium, andPhosphate Metabolism. Chapter 13. 2006 American Society for Bone and Mineral Research: 80.

12. Channa N Jayasena, Mohammad Mahmud, Fausto Palazzo, Mandy Donaldson, Karim Meeran, Waljit S Dhillo. Utility of the urine calcium-to-creatinine ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcaemic patients with vitamin D deficiency. Ann Clin Biochem March 2011; 48: 126-129.

13. Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G. Relationship between serum parathyroid hormone levels, vitamin D suffi ciency and calcium intake. JAMA 2005; 294: 2336-2341.

14. Elena Pérez González, F. Santos Rodríguez, E. Coto García. Magnesium homeostasis. Etiopathogeny, clinical diagnosis and treatment of hypomagnesaemia. A case study. Nefrologia 2009; 29: 518-524.

15. Quamme GA. Renal magnesium handling: new insights in understanding old problems. Kidney Int 1997; 52: 1180.

16. Abdullah MAA , Sandawana WM, Falhammar H; Magnesium and Human Health: Perspectives and Research Directions: Hindawi International Journal of Endocrinology; Volume 2018, Article ID 9041694, 17 pages https://doi.org/10.1155/2018/9041694

17. Murray J. Favus, David A. Bushinsky, and Jacob Lemann Jr. Regulation of Calcium, Magnesium, andPhosphate Metabolism. Chapter 13. 2006 American Society for Bone and Mineral Research: 81, 82.

18. Kahvecioğlu S. Hipofosfatemi Tanı ve Tedavisi: Turkiye Klinikleri J Nephrol-Special Topics 2014; 7: 56-59.