Abstract. Abnormal uterine bleeding is one of the most common presentations in gynecology practice with too many causes. Acute promyelocytic leukemia is one of the serious causes of uterine hemorrhage. Frequency and severity of hemorrage seen in acute promyelocytic leukemia is often associated with disseminated intravascular coagulation which can be life-threatening. A 37-year-old women was admitted to the emergency room with acute severe uterine bleeding, increasing weakness and weight loss. There was no gynecologic pathology that could clarify the situation. High suspicion of acute promyelocytic leukemia was noticed during evaluation. All-trans retinoic acid treatment with aggressive blood product support was started immediately. Pathological examination of sternal bone marrow confirmed the suspicions. Our aim is to report a case of massive uterine hemorrhage leading to diagnosis of acute promyelocytic leukemia for the first time and to take attention on acute promyelocytic leukemia as a very rare cause of uterine hemorrhage. Key words: Uterine hemorrhage, thrombocytopenia, acute promyelocytic leukemia, anemia