Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic interstitial lung disease with Langerhans cell infiltration in the lung. PLCH X has non-spesific symptoms, and most patients have smoking history. A combination of stellate nodules, reticular and nodular opacities, upper zone cysts or honeycombing, preservation of lung volume and costophrenic angle sparing are highly specific for PLCH. To contribute to the literature, two cases are presented. First case is 30 years old man with 10 pack/years smoking history was admitted with cough and persevering interstitial opacities. Second case is 34 years old man with 15 pack/years smoking history was admitted with persistant cough. On thorax CT the first case had reticulonodular opacities at the perifery of the upper and middle zones, second case had multiple parenchymal cystic nodular lesions. Open lung biopsy performed, immunohistochemical examination CD1a, CD68, S100 detecting antigenpositive and histologically and radiologically confirmed diagnosed of PLCH.
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1. Tazi A, Soler P, Hance AJ. Adult pulmonary Langerhans' cell histiocytosis. Thorax 2000; 55: 405-416.
2. Vassallo R, Ryu JH, Colby TV, Hartman T, Limper AH. Pulmonary Langerhans'-cell histiocytosis. N Engl J Med 2000; 342: 1969- 1978.
3. Vassallo R, Ryu JH. Pulmonary Langerhans' cell histiocytosis. Clin Chest Med 2004; 25: 561-571.
4. Sundar KM, Gosselin MV, Chung HL, Cahill BC. Pulmonary Langerhans cell histiocytosis: emerging concepts in pathobiology, radiology, and clinical evolution of disease. Chest 2003; 123: 1673-1683.
5. Tazi A. Adult pulmonary Langerhans' cell histiocytosis. Eur Respir J 2006; 27: 1272-1285.
6. Basset F, Corrin B, Spencer H, et al. Pulmonary histiocytosis X. Am Rev Respir Dis 1978; 118: 811-820.
7. Vassallo R, Limper AH. Pulmonary Langerhans cell histiocytosis. Interstitial Lung Disease, 4th ed, King TE Jr, Schwarz MI (Eds), B.C. Decker, Hamilton, ON, Canada 2003. p.838.
8. Kulwiec EL, Lynch DA, Aguayo SM, Schwarz MI, King TE Jr. Imaging of pulmonary histiocytosis X. Radiographics 1992; 12: 515-526.
9. Lacronique J, Roth C, Battesti JP, Basset F, Chretien J. Chest radiological features of pulmonary histiocytosis X: a report based on 50 adult cases. Thorax 1982; 37: 104-109.
10. Favara BE, Feller AC, Pauli M, et al. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol 1997; 29: 157-166.
11. Komp DM. Historical perspectives of Langerhans cell histiocytosis. Hematol Oncol Clin North Am1987; 1: 9-21.
12. Crausman RS, Jennings CA, Tuder RM, et al. Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology. Am J Respir Crit Care Med 1996; 153: 426-435.
13. Knight RK. Haemoptysis in eosinophilic granuloma. Br J Dis Chest 1979; 73: 181-186.
14. Caminati A, Harari S. Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis. Proc Am Thorac Soc 2006; 3: 299- 306.
15. Kim HJ, Lee KS, Johkoh T, et al. Pulmonary Langerhans cell histiocytosis in adults: highresolution CT-pathology comparisons and evolutional changes at CT. Eur Radiol 2011; 21: 1406-1415.
16. Vassallo R, Ryu JH, Schroeder DR, Decker PA, Limper AH. Clinical outcomes of pulmonary Langerhans'-cell histiocytosis in adults. N Engl J Med 2002; 346: 484-490.
17. Krajicek BJ, Ryu JH, Hartman TE, Lowe VJ, Vassallo R. Abnormal fluorodeoxyglucose PET in pulmonary Langerhans cell histiocytosis. Chest 2009; 135: 1542-1549.
18. Higashi K, Ueda Y, Seki H, et al. Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma. J Nucl Med 1998;39: 1016-1020.
19. Erasmus JJ, McAdams HP, Patz EF, et al. Evaluation of primary pulmonary carcinoid tumors using FDG-PET AJR 1998; 170: 1369-1373.
20. Suri HS, Yi ES, Nowakowski GS, Vassallo R. Pulmonary lan-gerhans cell histiocytosis. Orphanet J Rare Dis 2012; 7: 16.
21. Juvet SC, Hwang D, Downey GP. Rare lung diseases III: pul-monary Langerhans' cell histiocytosis. Can Respir J 2010; 17: 55-62.