Detection of Diseases, In Renal Donor Patients, During the Posttransplant Period and Researching Risk Factors

Kidney donors are followed up periodically for health problems such as chronic renal failure(CRF), hypertension(HT), diabetes mellitus(DM) that may develop after transplantation. The aim of this study was to determine the disease and to investigate the risk factors in renal donors followed in the outpatient clinic of the nephrology. In this study, 40 patients with renal donors aged between 18-75 years who were admitted to the nephrology clinic were included. From all donors; anamnesis was taken to determine if there was any disease after kidney transplantation and physical examinations were performed.Donors have previously looked at; 24-hour urinary glomerular filtration rate(GFR) and proteinuria measurement, creatinine, alanine aminotransferase(ALT), fasting glucose, hemoglobin A1c(HgbA1c) values were recorded. According to the physical examination and laboratory results of the donors, systemic disease after transplantation and risk factors were evaluated. Of the 40 donors included in the study, 29(72%) were female and 11(18%) were male. In the post-transplant background; 3(7.5%) had DM, 6(15%) had HT and 1(2.5%) had both DM and HT. The mean GFR was 81.6±21.3 ml/min. The viral markers of the donors were negative for anti-HCV, anti-HIV and HbsAg. As a result of the study, the incidence of diseases such as DM, HT, CRF in the follow-up of kidney donors admitted to our clinic was found to be the same as in the community. The fact that the incidence of donor diseases after transplantation is the same as the incidence in the community leads to a better option in the treatment of end-stage renal disease.

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1.National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002; 39: 1-266.

2. Kidney Disease: Improving Global Outcomes. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Volume 3, İssue 1, January 2013; 5-146.

3. Turkish Society of Nephrology and the SBA, "the Turkey Nephrology, Dialysis and Transplantation", Ankara 2013; 1-90.

4. Ministry of Health Statistics Annuals and DYOB data (July 2014)

5. Gibney EM, Parikh CR, Garg AX. Age, gender, race, and associations with kidney failure following living kidney donation. Transplant Proc 2008; 40: 1337-1340.

6. Fehrman-Ekholm I, Nord.n G, Lennerling A, et al. Incidence of end-stage renal disease among live kidney donors. Transplantation 2006; 82: 1646- 1648.

7. Mjøen G, Hallan S, Hartmann A, et al. Long-term risks for kidney donors. Kidney Int 2014; 86: 150- 162.

8. Muzaale AD, Massie AB, Wang MC, et al. Risk of end-stage renal disease following live kidney donation. JAMA 2014; 311: 570-579.

9. Segev DL, Muzaale AD, Caffo BS, et al. Perioperative mortality and long-term survival following live kidney donation. JAMA 2010; 303: 950-959.

10. Young A, Hodsman AB, Boudville N, et al. Bone and mineral metabolism and fibroblast growth factor 23 levels after kidney donation. Am J Kidney Dis 2012; 59: 740-761.

11. Ibrahim HN, Foley R, Tan L, et al. Long-term consequences of kidneydonation. N Engl J Med 2009; 360: 459-469.

12. Satman I, Omer B, Tutuncu Y, et al; TURDEPIIV Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol. 2013; 28: 169-180.

13. Hypertension risk in living kidney donors: an analysis of health administrative data in Ontario, Canada. Transplantation 2008; 86: 390-399.