Kozmetik Bebek Yağlarında Dört Parabenin Tayini için Derin Ötektik Çözücülere Dayanan Vorteks Destekli Mikro Ekstraksiyon ve Box-Behnken Tasarımı ile Optimizasyon

Bu çalışma kozmetik bebek yağlarında derin ötektik çözücülere (DES'ler) dayalı vorteks destekli mikroekstraksiyon ile dört parabenin mikro ekstraksiyonu ve tayinini sunmaktadır. En uygun DES, ChCl-etilen glikol mol oranları bu çalışmada kullanılmak üzere 1:2 olarak belirlenmiştir. DES türlerinin etkisi, geleneksel tek faktörlü deneyde araştırılmıştır. DES hacmi, seyreltme çözücü hacmi ve vorteks süresinin ekstraksiyon geri kazanımı üzerindeki etkisi Box-Behnken tasarımı ile incelenmiş ve optimize edilmiştir. Optimum koşullar belirlendikten sonra, DES'e dayalı vorteks destekli mikro ekstraksiyon, kalibrasyon eğrisi 0.1-100 µg mL-1 konsantrasyon tüm parabenler için çizildi. Kozmetik bebek yağı numunelerindeki parabenlerin geri kazanım değerleri % 82.02-101.95 aralığındadır ve RSD'ler %1.64 ile %2.91 arasında değişmektedir. Bu geliştirilen yöntem, benzer yapıdaki kozmetik ürünlerden parabenlerin ekstraksiyonu için çok uygun ve etkili bir yöntemdir.

Anahtar Kelimeler:

Derin ötektik çözücüler, paraben, sıvı faz mikroekstraksiyon, Box-Behnken tasarımı

A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design

This study presents microextraction and determination of four parabens by vortex-assisted microextraction based on deep eutectic solvents (DESs) in cosmetic baby oils. The most suitable DES, ChCl-ethylene glycol mole ratios of DES were determined as 1:2 for use in this study. The effect of DES types has been explored at traditional one factor experiment at a time. The effect of DES volume, dilution solvent volume and vortex time on extraction recovery were examined and optimized by the Box-Behnken design. After optimum conditions were determined, vortex-assisted microextraction based on DES, 0.1-100 µg mL-1 concentration in the range of the calibration curve was plotted for all parabens. The recovery values of parabens in cosmetic baby oil samples were in the range of 82.02-101.95% and the RSDs were varied from 1.64% to 2.91%. This developed method is very suitable and effective method for the extraction of parabens from cosmetic products of similar structure.

Keywords:

Deep eutectic solvents, paraben, liquid phase microextraction, Box-Behnken design,

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