İsa BAŞPINAR, Mehmet Akif KARAMERCAN, Figen COŞKUN, Yavuz KATIRCI

YÜKSEK DOZ DAPSON ALIMINA BAĞLI METHEMOGLOBİNEMİ OLGUSU

Dapson potent antiinflamatuar ve antiparazitik etkileri olan Lepra tedavisi için kullanılan birilaçtır. Nadiren eritrosit içerisinde yer alan hemoglobin redüktaz enzimini inhibe ederek,hemoglobinin oksidasyonunu azaltır. Tedavide metilen mavisi ve hemodiyaliz ve destektedavileri uygulanır. Bu calismamizda, kasıtlı olarak 4 gr Dapson alımına bağlı olusan birmethemoglobinemi tablosunu sunmayı amaçladık

Anahtar Kelimeler:

Dapson, methemoglobinemi, acil tıp

A Case of Dapsone Overdose Induced Methemoglobinemia

Dapsone is a drug with potent anti-inflammatory and anti-parasitic activities, which waspreviously used almost exclusively for the treatment of leprosy. Dapson rarely induce oxidationof haemoglobin which overwhelms the activity of intrinsic red cell methaemoglobin reductaseresulting in significant methaemoglobinaemia. Methylene blue and hemodialysis are consideredas treatment options of metheamoglobinemia together with supportive treatment. Here in wepresent a case of methemoglobinemia due to intentional ingestion of 4 gr dapson

Keywords:

Dapson, methemoglobinemia, emergency medicine,

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