Uncommon Organic Psychosis: an Adolescent Case ofAnti-N-Methyl-D-Aspartate Receptor Encephalitis

Psikotik belirtiler tanılamanın bazen güç olduğu çok sayıda nörolojik ve genel tıbbi durumlarda ortaya çıkabilir. Olgu sunumunun konusu, akut psikotik belirtilerle gelen ve Anti-N-Metil-D-Aspartat Reseptor (Anti-NMDAR) ensefaliti tanısı alan 16 yaşında kızdır. Bu olgu sunumunda, Anti-NMDAR ensefalitinin ana özellikleri vurgulandı ve gözden geçirildi. Klinisyenler, özellikle psikiyatristler, akut psikotik belirtiler, dezorganize davranışlar, azalmış bilinç düzeyi ve yeni başlayan nöbetleri olan genç kız hastalarda Anti-NMDAR ensefaliti ayırıcı tanısını düşünmeli ve bir süre laboratuar ve görüntüleme testlerinin negatif olabileceğini hatırlamalıdırlar.

Nadir organik psikoz: Bir ergen Anti-N-Metil-D-Aspartat reseptor ensefaliti olgusu

Psychotic symptoms may present in many neurological and general medical conditions in which, diagnosing is sometimes difficult. We reported a 16-year-old female presenting acute psychotic symptoms and diagnosed with Anti-N-Methyl-D-Aspartate Receptor (Anti-NMDAR) encephalitis. In this case report, main characteristics of anti-NMDAR encephalitis were highlighted and reviewed. Clinicians, especially psychiatrists, should consider a differential diagnosis of anti-NMDAR encephalitis in young, female patients with acute onset of psychotic symptoms, disorganized behaviors, decreased level of consciousness and new onset seizures, and remember that laboratory and imaging tests can be negative for a period of time.

Kaynakça

1. Algon S, Yi J, Calkins ME, Kohler C, Borgmann-Winter KE. Evaluation and treatment of children and adolescents with psychotic symptoms. Curr Psychiatry Rep 2012; 14:101-110.

2. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7:1091-1098.

3. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011; 10:63-74.

4. Wandinger KP, Saschenbrecker S, Stoecker W, Dalmau J. Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol 2011; 231:86-91.

5. Florance NR, Davis RL, Lam C, Szperka C, Zhou L, Ahmad S, Campen CJ, Moss H, Peter N, Gleichman AJ, Glaser CA, Lynch DR, Rosenfeld MR, Dalmau J. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol 2009; 66:11-18.

6. Armangue T, Petit-Pedrol M, Dalmau J. Autoimmune encephalitis in children. J Child Neurol 2012; 27:1460-1469.

7. Luca N, Daengsuwan T, Dalmau J, Jones K, deVeber G, Kobayashi J, Laxer RM, Benseler SM. Anti-N-methyl-D-aspartate receptor encephalitis: a newly recognized inflammatory brain disease in children. Arthritis Rheum 2011; 63:2516-2522.

8. Maggina P, Mavrikou M, Karagianni S, Skevaki CL, Triantafyllidou A, Voudris C, Katsarou E, Stamogiannou L, Mastroyianni S. Anti-N-methyl-D-aspartate receptor encephalitis presenting with acute psychosis in a preteenage girl: a case report. J Med Case Rep 2012; 6:224.

9. van de Riet EH, Schieveld JN. First-onset psychosis, anti-NMDAR encephalitis, schizophrenia and Consultation-Liaison psychiatry. Gen Hosp Psychiatry 2013; 35:442-443.

Kaynak Göster

  • ISSN: 1018-8681
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1984

4.8b 2.9b

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