Pınar TALAY PINAR, Tamer TULUK, Zühre ŞENTÜRK

Pravastatin′in Camımsı Karbon Elektrot üzerinde Kare-dalga Voltametrisi ile İlaç Formülasyonunda Tayini

Lipit düşürücü ilaç olan Pravastatin′in, camımsı karbon elektrot üzerindeki elektrokimyasal davranışı, Britton-Robinson tamponu içerisinde dönüşümlü voltametri ve kare-dalga voltametrisi teknikleri kullanılarak araştırılmıştır. Dönüşümlü voltametrik çalışmalar, molekülün tersinmez olarak yürüyen yükseltgenmesinin difüzyon-kontrollü olduğunu göstermiştir. Kare-dalga voltametrisi kullanılarak, Pravastatin′in pH 2.0 değerinde +1.24 V (vs. Ag/AgCl) gerilim değerinde 2.4×10-7-2.8×10-6 M derişim aralığında (saptama sınırı, 5.0×10-8 M) tayini gerçekleştirilmiştir. Önerilen yöntem, Pravastatin′in tablet ilaç şeklinden tayinine başarıyla uygulanmıştır.

Anahtar Kelimeler:

Pravastatin, Kare-dalga voltametrisi, Camımsı karbon elektrot

Determination of Pravastatin in Drug Formulation by Square-wave Voltammetry on a Glassy Carbon Electrode

The electrochemical behavior of Pravastatin, a lipid-lowering drug, on a glassy carbon electrode was explored in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclic voltammetric studies indicated that the compound underwent irreversible oxidation, which was a diffusion-controlled process. Using square-wave voltammetry, Pravastatin could be determined at +1.24 V (vs. Ag/AgCl) in the concentration range 2.4×10-7-2.8×10-6 M at pH 2.0, with a detection limit of 5.0×10-8 M. The suggested method was successfully applied for the assay of Pravastatin in tablets.

Keywords:

Pravastatin, Square-Wave Voltammetry, Glassy Carbon Electrode,

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