Prematür ejakülasyon tedavisinde güncel farmakolojik ajanlar

Bu çalışmada prematür ejakülasyon (PE)un güncel medikal tedavisini gözden geçirmeyi ve değerlendirmeyi amaçladık. PE erkekleri en sık etkileyen seksüel rahatsızlıktır. Her yaş grubundaki erkekleri ve partnerlerinin yaşam kalitesini ciddi ölçüde etkileyebilir. PE için çeşitli tedaviler denenmektedir. Psikolojik tedavi PE hastaları için faydalı olabilmektedir. Lidokain veya lidokain-prilokain içeren çeşitli kremler PE tedavisinde kullanılmaktadır. Son zamanlarda serotonin geri alım inhibitörleri (SSRI) ejekülasyonu geciktirici yan etkilerinden dolayı ön plana çıkmıştır. SSRIların birçok yan etkisi ve uzun süreli yarı- lanma ömürleri daha az yan etkisi olan ve potent formların geliştirilmesini gerektirmiştir. Yeni bir SSRI olan Dapoxetin ile yapılan çalışmalarda ümit verici sonuçlara ulaşılmıştır.

Current pharmacological agents for the treatment of premature ejaculation

This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious impact on the quality of life for men and their partners. A wide variety of therapeutic modalities have been tried for treatment of premature ejaculation. Psychological therapies may be helpful for patients with complaint PE. Several topical therapies have been used including lidocaine cream, lidocaine-prilocaine cream. There has been recent interest in the selective serotonin reuptake inhibitors (SSRI) for the treatment of PE, due to the fact that one of their common side effects is delayed ejaculation. Currently used SSRIs have several non-sexual side effects and long half lives, therefore there has been interest in developing a short acting, and efficacious SSRI that can be used on-demand for PE. Dapoxetine has been recently evaluated for the treatment of PE by several groups, and results so far appear promising.

___

  • 1. Montorsi F. Prevalence of premature ejaculation: A global and regional perspective. J Sex Med 2005;2 (Suppl 2):96- 102.
  • 2. Screponi E, Carosa E, Di Stasi SM, et al. Prevalence of chronic prostatitis in men with premature ejaculation. Urology 2001;58:198-202.
  • 3. McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: A single-blind placebo controlled crossover study. J Urol 1998;159:1935-1938.
  • 4. Jannini EA, Lombardo F, Lenzi A. Correlation between ejaculatory and erectile dysfunction. Int J Androl 2005;28 (Suppl 2):40–45.
  • 5. Montague DK, Jarow J, Broderick GA, et al. AUA guideline on the pharmacologic management of premature ejaculation. J Urol 2004;172:290-294.
  • 6. Sunay D, Sunay M, Aydoğmuş Y, et al. Acupuncture versus paroxetine for the treatment of premature ejaculation: a randomized, placebo-controlled clinical trial. Eur Urol. 2011 May;59:765-771.
  • 7. Atikeler MK, Gecit I, Senol FA. Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia 2002;34:356–359.
  • 8. Atan A, Basar MM, Tuncel A, et al. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology 2006;67:388–391.
  • 9. Dinsmore WW, Hackett G, Goldmeier D, et al. Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. B J U Int 2006;99:369–375.
  • 10. Dinsmore WW, Wyllie MG. PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo controlled study. B J U Int 2009;103:940–949.
  • 11. Gurkan L, Oommen M, Hellstrom WJG. Premature ejaculation: current and future treatments. Asian J Androl 2008;10:102–109.
  • 12. Giuliano F, Clement P. Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 2006;50:454–466.
  • 13. Kwon OY, Kam SC, Choi JH, et al. Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation. Int J Impot Res 2011;23:213–219.
  • 14. Waldinger MD, Zwinderman AH, Schweitzer DH, et al. Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 2004; 16: 369–381.
  • 15. Koyuncu H, Serefoglu EC, Yencilek E, et al. Escitalopram treatment for premature ejaculation has a negative effect on semen parameters. Int J Impot Res 2011;23:257–261.
  • 16. Tanrikut C, Feldman AS, Altemus M, et al. Adverse effect of paroxetine on sperm. Fertil Steril 2010;94:1021–1026.
  • 17. Tanrikut C, Schlegel PN. Antidepressant-associated changes in semen parameters. Urology 2007;69:185–17.
  • 18. Waldinger MD, Zwinderman AH, Olivier B. SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol 2001;21:556–560.
  • 19. Waldinger MD, Hengeveld MW, Zwinderman AH, et al. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 1998;18:274–281.
  • 20. Wang WF, Dong DX, Cen S. Medication for premature ejaculation. Natl J Androl 2003;9:221-225.
  • 21. Yilmaz U, Tatlisen A, Turan H, et al. The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation. J Urol 1999;161:107-111.
  • 22. Modi NB, Dresser MJ, Simon M, et al. Single and multiple dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. J Clin Pharmacol 2006;46:301–309.
  • 23. McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998; 159: 1935-1938.
  • 24. Gurkan L, Oommen M, Hellstrom WJG. Premature ejaculation: current and future treatments. Asian J Androl 2008;10:102-109.
  • 25. Dadfar M. Salvage use sitalopram for treatment of fluoxetine- resistant premature ejaculation in recently married men. Urology J 2010;7:40-44.
  • 26. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, Washington DC: American Psychiatric Association Press, 1994.
  • 27. Hsu JH, Shen WW. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry Med 1995;25:191–201.
  • 28. Shen WW, Hsu JH. Female sexual side effects associated with selective serotonin reuptake inhibitors: a descriptive clinical study of 33 patients. Int J Psychiatry Med 1995;25:239–248.
  • 29. Atmaca M, Kuloglu M, Tezcan E, et al. Serum leptin levels in patients with premature ejaculation before and after citalopram treatment. BJU Int 2003;91:252-254.
  • 30. Pryor JL, Althof SE, Steidle C, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomizedcontrolled trials. Lancet 2006;368:929-937.
  • 31. Andersson KE, Mulhall JP, Wyllie MG. Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for “on demand” treatment of premature ejaculation. B J U Int 2006;97:311-315.
  • 32. Pryor JL, Althof SE, Steidle C, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomizedcontrolled trials. Lancet 2006;368:929-937.
  • 33. Montejo AL, Llorca G, Izquierdo JA, et al. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psycholotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001;62:10-21.
  • 34. Gokce A, Halis F, Demirtas A, Ekmekcioglu O. The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a doubleblind laboratory setting study. BJU Int 2011;107:1274- 1277.
  • 35. Atan A, Basar MM, Tuncel A, et al. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology 2006;67:388-391.
  • 36. Sommer TK, MJ Mathers. Treatment of premature ejaculation: a comparative vardenafil and SSRI crossover study. J Urol 2005;173:171-175.
Dicle Tıp Dergisi-Cover
  • ISSN: 1300-2945
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1963
  • Yayıncı: Cahfer GÜLOĞLU
Sayıdaki Diğer Makaleler

Oseltamivir use for viral pneumonia in newborns

BANU AYDIN, Nihan HOŞAĞASI, Ayşegül ZENCİROĞLU, NAZMİYE NİLGÜN KARADAĞ, SERDAR BEKEN, Dilek DİLLİ, Nurullah OKUMUŞ

Total antioxidant and oxidant status in obese children without insulin resistance

AYŞEGÜL DOĞAN DEMİR, UFUK ERENBERK, İlker Tolga ÖZGEN, Emin ÖZKAYA, Aysel TÜRKMEN VAHAPOĞLU, M. Ruşen DÜNDARÖZ, Özcan EREL

Osteogenesis imperfektalı yetişkin hastada zoledronik asit tedavisi: Bir olgu ve literatür derlemesi

Levent YAZMALAR, İBRAHİM BATMAZ, Zübeyr DAĞLI, Erkam HATTAPOĞLU, Mustafa Akif SARIYILDIZ

Endobutton technique for the treatment of acute acromioclavicular joint dislocations

RAİF ÖZDEN, Vedat URUÇ, İBRAHİM GÖKHAN DUMAN, Yunus DOĞRAMACI, AYDINER KALACI, Erkam KÖMÜRCÜ

İnfraauriküler rekürren dermatofibrosarkoma protuberans'ın cerrahi eksizyonu ve bilobe flep ile rekonstrüksiyonu

Fuat BULUT, Mehmet AKDAĞ, Ali Cemal YILMAZ, Bilal KAYA, Sevim ÖZTEKİN

Bilateral elastofibroma dorsi olgusu

ERDOĞAN DADAŞ, Bülent PETİK, Ayşe Nur AKATLI, Deniz ÇOLAK

Gebelerde Toxoplasma gondii, rubella ve sitomegalovirüs seroprevalansı

Murat BAKACAK, Mehmet Sühha BOSTANCI, Bülent KÖSTÜ, Önder ERCAN, Salih SERİN, Fazıl AVCI, Zeyneb BAKACAK

Seroprevalance of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women

Murat BAKACAK, Mehmet Sühha BOSTANCI, Bülent KÖSTÜ, Önder ERCAN, Salih SERİN, Fazıl AVCI, Zeyneb BAKACAK

Rotator manşet yırtığı tamirinde mini açık yaklaşımla tek-sıra sütür-ankor tekniğinin klinik ve radyolojik sonuçları

Serhat KARAPINAR, Vedat URUÇ, RAİF ÖZDEN, İBRAHİM GÖKHAN DUMAN, Yunus DOĞRAMACI, AYDINER KALACI

An endoscopic cadaveric study: Accessory maxillary ostia

ALPER SİNDEL, MURAT TURHAN, Eren OGUT, Mehmet AKDAĞ, ASLI BOSTANCI TOPTAŞ, MUZAFFER SİNDEL