Zuhal UCKUN SAHİNOGULLARİ

Investigation of the 1249G>A Genetic Variation of ABCC2 Drug Transporter Gene in the Turkish Population

Objectives: ATP binding cassette (ABC) transporters are a major superfamily of drug transporters and provide active transport of diverse substrates across cell membranes of several cell types. Genetic variations that affect function in ABCC2 gene may alter therapeutic outcome and the risk of toxicity to substrate drugs. The goal of the current survey was to ascertain the allele and genotype frequencies of ABCC2 1249G>A polymorphism in a Turkish population and to compare the findings obtained with the frequencies of previously reported populations. Methods: The frequencies of the ABCC2 1249G>A gene polymorphism were determined in 101 healthy Turkish individuals using polymerase chain reaction-restriction fragment length polymorphism methods. Results: The frequencies of GG, GA and AA genotypes were 67.3%, 28.7% and 4.0%, respectively. The frequencies were 81.7% for G allele and 18.3% for A allele. The frequencies of genotypes were in concurrence with Hardy-Weinberg Equilibrium. Significant distinctions were observed in the comparison of the study data with the results of some populations of East and South Asian ancestries. Conclusions: The current study presents the distribution of genotype and allele frequencies of ABCC2 1249G>A polymorphism in the Turkish population. As far as is known, this is the first study about the frequencies of the ABCC2 1249G>A polymorphism in the Turkish population. This study may ensure valuable information for evaluating inter-individual differences in drug response, estimating adverse reactions and improving disease management, briefly, it can contribute to pharmacogenetic and epidemiological studies.

Anahtar Kelimeler:

ABCC2 1249G>A, MRP2, V417I polymorphism, drug transporters, Turkish population

PDF

___

1. Choi JR, Kim JO, Kang DR, et al. Genetic variations of drug transporters can influence on drug response in patients treated with docetaxel chemotherapy. Cancer Res Treat. 2015; 47: 509-17.
2. Uckun Sahinogullari Z, Canacankatan N, Canacankatan M. Genotype and allele frequencies of SLCO1B1 g.89595 T>C polymorphism in a healthy Turkish population. J Res Pharm. 2019; 23: 1149-56.