Objective: Breastfeeding is very important for the development and well-being of an infant. Other perinatal factorsalso influence the well-being of the infant like the method of conception, delivery method and multiple pregnancy. Ouraim in this study is to investigate the effects of these factors on the development of retinopathy of prematurity (ROP).Methods: The records of premature infants who were screened for ROP between 2015 and 2018. Gestational age (GA),birth weight (BW), sex, time spent in neonatal intensive care unit (NICU), assisted reproduction method, method ofdelivery, breastfeeding and multiple births were noted. The presence of ROP, stage and zone of the disease, treatmentfor ROP were recorded.Results: GA and BW were significantly lower and time spent in NICU was significantly longer in infants with ROP(p
Amaç: Anne sütü, bir bebeğin büyüme ve gelişiminde çok önemli bir yere sahiptir. Yardımcı üreme yöntemleri, doğum şekli ve çoğul gebelik de bebeğin sağlığını etkileyebilen perinatal faktörlerdendir. Bu çalışmadaki amacımız anne sütü, konsepsiyon yöntemi, doğum şekli ve çoğul gebeliğin prematüre retinopatisi (PR) gelişimi üzerindeki etkilerini araştırmaktır. Yöntemler: Prematüre doğum nedeniyle 2015 ve 2018 yılları arasında PR taraması yapılan bebeklerin kayıtları incelendi. Doğum haftası (DH), doğum ağırlığı (DA), yenidoğan yoğun bakım ünitesinde (YDYBÜ) yatış süresi, yardımcı üreme tekniği, doğum şekli, anne sütü alımı ve çoğul gebelik not edildi. Prematüre retinopatisi varlığı, hastalığın zonu ve evresi, tedavi gereksinimi ve gelişen sekeller kayıt edildi. Bulgular: Prematüre retinopatisi saptanan hastalarda DA ve DH diğer hastalara göre anlamlı olarak düşük, YDYBÜ yatış süresi anlamlı olarak daha uzundu (p
___
Goldman AS. Evolution of immune functions of the mammary gland and protection of the infant. Breastfeeding Medicine. 2012; 7: 132–42.
Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatric Research. 2007; 61: 2–8.
Savino F, Liguori SA. Update on breast milk hormones: leptin, ghrelin and adiponectin. Clinical Nutrition. 2008; 27: 42–7.
Dieterich CM, Felice JP, O'Sullivan E, Rasmussen KM. Breastfeeding and health outcomes for the motherinfant dyad. Pediatr Clin North Am. 2013; 60: 31-48.
Chien PF, Howie PW. Breast milk and the risk of opportunistic infection in infancy in industrialized and non-industrialized settings. Advances in Nutritional Research. 2001; 10: 69–104.
Kramer MS, Aboud F, Mironova E, et all. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008; 65: 578–84.
Hauck FR, Thompson JM, Tanabe KO, Moon RY, Vennemann MM. Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis. Pediatrics. 2011; 128: 103–10.
Kwan M, Buffler P, Abrams B, Kiley VA. Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep. 2004; 119: 521–35.
Li R, Grummer-Strawn LM, Fein SB. Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants? Pediatrics. 2010; 125: e1386–e93.
Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr. 2006; 84: 1043–54.
Ginovart G, Gich I, Verd S. Human milk feeding protects very low-birth-weight infants from retinopathy of prematurity: a pre-post cohort analysis. J Matern Fetal Neonatal Med. 2016; 29: 3790-5.
Heller CD, O'Shea M, Yao Q et all. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007; 120: 1-9.
Kim SJ, Port AD, Swan R, Campbell JP, Chan RVP, Chiang MF. Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol. 2018; 63: 618-37.
Early Treatment for Retinopathy Of Prematurity Cooperative Group: Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003; 121: 1684– 94
Bharwani SK, Green BF, Pezzullo JC, et all. Systematic review and meta-analysis of human milk intake and retinopathy of prematurity: a significant update. J Perinatol. 2016; 36: 913-20.
Hylander MA, Strobino DM, Pezzullo JC, Dhanireddy R. Association of human milk feedings with a reduction in retinopathy of prematurity among very low birthweight infants. J Perinatol. 2001; 21: 356-62.
Kao JS, Dawson JD, Murray JC et all. Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity. Acta Paediatr. 2011; 100: 347-51.
Shiozaki A, Yoneda S, Nakabayashi M et all. Multiple pregnancy, short cervix, part-time worker, steroid use, low educational level and male fetus are risk factors for preterm birth in Japan: a multicenter, prospective study. J Obstet Gynaecol Res. 2014; 40: 53-61.
Li WL, He L, Liu XH, Wang YM, Liu JQ. Analysis of risk factors for retinopathy of prematurity. Int J Ophthalmol. 2011; 4: 631-3.
Martínez-Cruz CF, Salgado-Valladares M, Poblano A, Trinidad-Pérez MC. Risk factors associated with retinopathy of prematurity and visual alterations in infants with extremely low birth weight. Rev Invest Clin. 2012; 64: 136-43.
Friling R, Axer-Siegel R, Hersocovici Z, et all. Retinopathy of prematurity in assisted versus natural conception and singleton versus multiple births. Ophthalmology. 2007; 114: 321-4.
Sutcliffe AG, Ludwig M. Outcome of assisted reproduction. Lancet. 2007; 370, 351–59.
Gebeşçe A, Uslu H, Keleş E et all. Evaluation of very low birth weight infants in the neonatal intensive care unit of a university hospital. Dicle Med J 2015; 42: 137- 42.
Barker L, Bunce C, Husain S, Adams GG. Is artificial reproductive technology a risk factor for retinopathy of prematurity independent of the generation of multiple births? Eur J Ophthalmol. 2017; 27:174-8.
Chan RV, Yonekawa Y, Morrison MA et all. Association between assisted reproductive technology and advanced retinopathy of prematurity. Clin Ophthalmol. 2010; 4: 1385-90.
Funnell CL, Dabbs TR. Assisted conception and retinopathy of prematurity: 8-year follow-up study. Eye (Lond). 2007; 21:383-6.
Manzoni P, Farina D, Maestri A et all. Mode of delivery and threshold retinopathy of prematurity in pre-term ELBW neonates. Acta Paediatr. 2007; 96: 221-6.
Abdel HA, Mohamed GB, Othman MF. Retinopathy of Prematurity: A Study of Incidence and Risk Factors in NICU of Al-Minya University Hospital in Egypt. J Clin Neonatol. 2012; 1:76-81.