Discriminating Borderline Ovarian Tumors from Ovarian Cancer: Focus on Systemic İnflammatory Response Markers

BACKGROUND/AIMS This study aims to investigate the preoperative diagnostic accuracy of systemic inflammatory response (SIR) markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), in discriminating borderline ovarian tumors (BOTs) from malignancy and, thereby, prevent over- or underdiagnosis in the management of BOTs and ovarian malignancy. MATERIAL and METHODS Medical records of 99 patients who underwent surgical treatment and had confirmed histopathologic diagnosis of primary malignant or BOT were retrospectively analyzed. The recommended cut-off values for preoperative NLR and PLR were determined using receiver operating characteristic. The associations of NLR and PLR with tumors’ malignancy potentials were analyzed using the Chi-square test or the Fisher’s exact test. RESULTS The mean NLR and PLR were significantly lower (p=0.002 and p=0.006, respectively) in BOTs group than in the epithelial ovarian carcinoma (EOC) group. Optimal cut-off points of NLR and PLR for discriminating BOTs and EOC group was 2.42 and 169.2, respectively. The likelihood of malignancy increased in group with NLR values >2.42 (p169.2 (p


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