CD133 and CD44 expression patterns in gliomas and meningiomas

CD133 ve CD44 sırasıyla glioblastoma multiforme (GBM) ve meningiomlarda geniş ölçüde tespitedilen hücre yüzey işaret molekülleridir. Yakın zamandaki moleküler çalışmalar CD133 müspetGBM hücrelerinin kanser kök hücrelerinin sahip olduğu düşünülen kendini yenileme veyineleme‟ özelliklerine sahip olduklarını göstermiştir. Benzer şekilde, CD44 yüzey işaretinin dedeğişik meningioma alttiplerinde olduğu bilinmektedir ve birkaç çalışmada CD44 miktarıylameningioma invazyonu arasında ilişki olduğu bildirilmiştir. Bu bağlamda, CD133 ve CD44 hücreyüzey işaret moleküllerinin sırasıyla GBM ve meningiomlardaki sunulma biçimlerini ve bumoleküllerin potansiyel kanser kök hücreleriyle olan ilişkilerini vurgulamayı amaçladık.

Glioma ve meningiomalarda CD133 ve CD44 ekspresyon paternleri

CD133 and CD44 are widely expressed cell-surface markers in glioblastoma multiforme (GBM)and meningiomas respectively. Recent molecular studies revealed that CD133-positive GBM cellshave cancer stem cell features with self-renewal and self-recapulating capacity. Similarly, it is alsoknown that CD44 is expressed differentially on various meningioma subtypes and several studiesin the literature reported that CD44 expression is correlated with the invasiveness of meningiomas.In this context, we aimed to highlight the expression patterns of CD133 and CD44 and theirimplications with the potential cancer stem cells in glioblastoma multiforme (GBM) andmeningiomas, respectively.

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Cumhuriyet Tıp Dergisi (ELEKTRONİK)-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Cumhuriyet Üniversitesi Tıp Fakültesi
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