Somayyeh ROSTAMZADEHMANSOUR, Sevil SHAHAMAT

A Novel Vehicle for Entrapment of Drugs: Doxorubicin-loaded bilayer-surface magnetite nanoparticle

Abstract. In the past few decades, Magnetite (Fe3O4) nanoparticles have attracted growing research interest that this material has many applications in medicine and drug delivery, Coated magnetic particles, called carriers are very useful for delivering chemotherapeutic drugs. We are herein reporting a synthesis of doxorubicin-loaded bilayer-surface magnetite nanoparticles. The particles were first stabilized with Stearic acid as a primary surfactant, followed by Maleic anhydride-methyl acrylate (MAN-MA) copolymer as a secondary surfactant to form nanoparticles with hydrophobic inner shell and hydrophilic corona. Then anticancer drug doxorubicin (DOX) was selected as a model Drug, That loaded at modified magnetic nanoparticles. The structural, morphological and magnetic properties of as-prepared sample were characterization by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra, scanning electron microscopy/energy dispersive x-ray analysis (SEM-EDAX) and magnetic measurements were investigated using vibrating sample magnetometer (VSM). The particles were exhibited super paramagnetic behavior at room temperature with saturation magnetization (Ms) about 50 emu/g magnetite. We demonstrate that the drug DOX is attached to the nanoparticles surface, that the binding of DOX to the nanoparticles was confirmed by FT-IR analysis. The present finding show that DOX loaded nanoparticles coated by copolymer are promising for magnetically targeted drug delivery.

Keywords:

Doxorubicin, loaded bilayer, magnetite nanoparticle novel vehicle, entrapment of drugs,

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