Kaveh TABRİZİAN, Abdolhossein MIRI, Elahe SHAHRAKI

Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of the Melilotus indicus (L) in male mice

Abstract. In current study, the antinociceptive and anti-neuropathic pain effects of hydroalcoholic extract of Melilotus indicus in male mice were assessed using formalin and hot plate tests, respectively. Cotton pellet- induced granuloma model was employed for anti- inflammatory assessments. Melilotus indicus hydroalcoholic extract (50 and 100 mg/kg, oral gavage) reduced the time and the number of lickings during the late phase of the formalin test. Anti-neuropathic pain properties were obtained with the dose of 100 mg/kg. Anti-inflammatory effect of this extract (100 mg/kg) was confirmed by a significant decrease in Cotton pellet weight.

Keywords:

Antinociceptive, Melilotus indicus Neuropathic pain, Formalin test, inflammati,

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Figure 1. Effects of melilotus indicus, morphine and diclofenac in the first (A and B) and second phase (C and D) of
the formalin test. Each value represents the mean ± S.E.M. (n=7). **p< 0.01 and ***p<0.001 significantly different
from the control animals.