ASYMMETRIC SYNTHESIS İN A REFORMATZKY REACTION PREPARATION OF OPTICALLY ACTIVE p-HYDROXY ACIDS
Reaction of benzaldehyde with optically active bromoacetic ester derivative I in a Refor* matzky reaction gives, after hydrolysis of the resulting ester, laevorotatory B-hydroxy-Bphenyl phenyl-propionic acid. Moreover, reaction of ethyi bromoacetate with acetophenone in the pre¬sence of zinc and 1,2:5,6-di-Odsopropylideno-a-D-glucofuranose (II) is accompanied by partial asymmetric synthesis as is shownby hydrolysis of the resulting ester to laevorotatory B-hydroxy -B-phenylbutyric acid.
Keywords:
ASYMMETRIC, REFORMATZKY REACTION p-HYDROXY ACIDS,
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- Communications Faculty of Sciences University of Ankara Series B Chemistry and Chemical Engineering
- ISSN: 1303-6017
- Başlangıç: 1948
- Yayıncı: Ankara Üniversitesi
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