A comparative study of classifiers for early diagnosis of gestational Diabetes Mellitus

Gestational Diabetes Mellitus (GDM), usually found deploying a medical test called the Oral Glucose Tolerance Test (OGTT), is a prevalent complication during pregnancy. Early detection of GDM and identifying the most influential risk factors of GDM pose to be a challenging problem and is found to be crucial as GDM has dreadful health indications for both mother and the baby. The performances of computational techniques like Radial Basis Function (RBF) neural network and Multilayer Perceptron Network (MLP) were collated with that of the statistical technique Discriminant Analysis (DA) on real time GDM datasets for diagnosis of GDM in multigravida pregnant women, specifically women who have been pregnant more than once, without even a visit to the hospital. The most influential risk factors were identified using DA while the overall performance of MLP beyond doubt established itself to be the most effective technique for early diagnosis of GDM in women during pregnancy.

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  • Seshiah, V., Balaji, V., Balaji, MS., Sanjeevi, CB. and Green, A, Gestational Diabetes Mellitus in India, J Assoc Physicians India, 52(2004),707-1.
  • Seshiah, V., Balaji, V., Balaji, MS., et. al. Prevalence of gestational diabetes mellitus in South India (Tamil Nadu)a community based study, J Assoc Physicians India, 56(2008), 329-333.
  • Metzger, BE. and Coustan, DR., Summary and recommendations of the Fourth International Workshop Conference on Gestational Diabetes Mellitus: The Organizing Committee, Diabetes Care, 21(1998) No.2, B161-7.
  • Kasper, DL., Harrison's principle of Internal Medicine, 6th ed. McGraw Hill Books(2005) , 2180-2186.
  • Alberti, KG. and Zimmett, PZ., Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation, Diabet Med,15(1995) No.7, 539-553.
  • Crowther, CA., Hiller, JE., Moss, JR., et. al. Effect of treatment of gestational diabetes mellitus, N Engl J Med, 352(2005) No.24, 2477-86.
  • Gayle, C., Germain, S., Marsh, MS., et. al, Comparing pregnancy outcomes for intensive versus routine antenatal treatment of GDM based on a 75 gm OGTT 2-h blood glucose (>140 mg/dl), Diabetologia,53(2010), No 1, S435.
  • Wahi, P., Dogra, V., Jandial, K., et. al, Prevalence of Gestational Diabetes Mellitus and its Outcomes in Jammu Region, J Assoc Physicians India, 59(2011), 227-30.
  • Pattinson, R., Kerber, K., Buchmann, E., et. al, Stillbirths: how can health systems deliver for mothers and babies?, Lancet, 377(2011), No.9777,1610-23.
  • Nanda, S., Savvidou, M., Syngelaki, A., Akolekar, R. and Nicolaides, KH., Prediction of Gestational Diabetes Mellitus by maternal factors and biomarkers at 11 to 13 weeks, Prenatal Diagnosis Published in Wiley Online Library, 31(2011), No.2, 135-141.
  • Tran, TS., Hirst, JE., Do, MA., Morris, JM. and Jeffery, HE., Early Prediction of Gestational Diabetes Mellitus in Vietnam, Diabetes Care, 36(2013), No.3, 618-624.
  • Okeh, UM. and Oyeka, ICA., Receiver Operating Characteristic Curve Analysis Of Diagnostic Tests Results For Gestational Diabetic Mellitus, Journal of Mathematics, 8(2013) No.1, 11-17.
  • Zhang, C., Song, J. and Wu, Z., Fuzzy Integral Applied to the Diagnosis of Gestational Diabetes Mellitus, Sixth International Conference on Fuzzy Systems and Knowledge Discovery. Tianjin, China, IEEE, 4(2009), 296-300.
  • Lohse, N., Marseille, E. and Kahn, JG., Development of a model to assess the cost-effectiveness of gestational diabetes mellitus screening and lifestyle change for the prevention of type 2 diabetes mellitus, International Journal of Gynaecology and Obstetrics, 115(2011), No.1, S20-S25.
  • Engelbrecht, AP., Computational Intelligence: An Introduction, Second Edition, John Wiley & Sons Ltd, 2007.
  • Bishop, CM., Neural Networks for Pattern Recognition, Oxford University Press, 1995.
  • Delican, Y., Ozyilmaz, L. and Yildirim, T., Evolutionary algorithms based RBF neural networks for Parkinson's disease diagnosis, 7th International Conference on Electrical and Electronics Engineering, IEEE(2011), 290-294.
  • Garcia, M., Lopez, MI., Hornero, R., Diez, A. and Poza, J., Utility of a Radial Basis Function Classifier in the Detection of Red Lesions in Retinal Images, World Congress on Medical Physics and Biomedical Engineering. Germany, IFMBE Proceedings Springer, 25(2009), No.11, 21-24.
  • Lee, J., Blain, S., Casas, M., Kenny, D., Berall, G. and Chau, T., A radial basis classifier for the automatic detection of aspiration in children with dysphagia, Journal of NeuroEngineering and Rehabilitation, Springer, 3(2006),1-14.
  • Vijayamadheswaran, R., Arthanari, M. and Sivakumar, M., Detection of diabetic retinopathy using radial basis function, International Journal of Innovative Technology & Creative Engineering,1(2011), 40-47.
  • Robert, J. and Howlett, C., Radial Basis Function Networks 2: New Advances Design. Physica- Verlag, 2001.
  • Garg, S., Patra, K., Pal, SK. and Chakraborty, D., Effect of different basis functions on a radial basis function network in prediction of drill flank wear from motor current signals, Soft Computing, Springer,12(2008) ,777-787.
  • Kurban, T. and Besdok, E., A Comparison of RBF Neural Network Training Algorithms for Inertial Sensor Based Terrain Classification, Sensors, 2009.
  • Mohamad, N., Ismet, RI., Rofiee, M., et al., Metabolomics and partial least square discriminant analysis to predict history of myocardial infarction of self-claimed healthy subjects: validity and feasibility for clinical practice, Journal of Clinical Bioinformatics, Springer, 5(2015), No.3.
  • Hosmer, DW., and Lemeshow, S., Applied Logistic Regression, John Wiley, New York, 1989.
  • Muller, PS., Sundaram, SM., Nirmala M. and Nagarajan E., Application of Computational Technique in Design of Classifier for Early Detection of Gestational Diabetes Mellitus. Applied Mathematical Sciences, 9(2015), No.67, 3327-3336.
  • Muller, PS. and Nirmala, M., Identifying most influential risk factors of Gestational Diabetes Mellitus using Discriminant Analysis, International Journal of Pure and Applied Mathematics,113(2017), No.10, 100-109.