Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia

Objective: Objective: Medicinal herbs offer natural remedies for various ailments because of their comprehensive effects. Scorzonera cinerea L. (Sc) is an edible wild plant and is used in traditional medicine against various diseases. The purpose of this study was to investigate the immune system effects of S. cinerea radical leaf extract in diabetic rats. Methods: The 5 groups were formed — Control, Diabetic, Sc-Dried, Sc-Frozen, and Acarbose. Adenosine deaminase (ADA), xanthine oxidase (XO), and myeloperoxidase (MPO) activities in liver and kidney tissues were analyzed. Hematological parameters were also evaluated. Results: ADA, XO, and MPO activities in both tissues significantly increased in diabetic conditions. However, Sc treatments significantly decreased liver ADA, liver and kidney XO, and liver and kidney MPO activities. There was no significant change in red blood cell (RBC) parameters. Although platelet (PLT) count and MPV were raised in the diabetic group, these parameters were reduced with Sc-Dried and Sc-Frozen treatment. While lymphocyte (LYM%) significantly decreased in defense cells in the diabetic group, neutrophil (NEU%), monocyte (MO%), and eosinophil (EOS%) elevated. However, a significant decrease was observed in NEU% and EOS% with Sc treatment. Conclusion: S. cinerea treatment can exert a potential immunoregulatory effect in diabetes. Thus, S. cinerea can be considered as an adjuvant to augment immune system on diabetes.

Keywords:

Adenosine deaminase, Hematology, Immunity, myeloperoxidase, Scorzonera cinerea xanthine oxidase,

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