NAZAL SEPTUM PERFORASYON TAMİRİNDE FASYA VE YAĞ DOKUSU KULLANIMI: DENEYSEL TAVŞAN MODELİ
Amaç: Bu çalışmanın amacı septum perforasyon tamirinde yeni bir metod ortaya koymaktır.. Gereç ve Yöntemler: Bu çalışmada 12 beyaz, erişkin Yeni Zelanda tavşanı kullanıldı.Tavşanlar eşit olarak iki gruba ayrıldı.Tüm tavşanlarda 4mm çaplı punch aleti(12.983 mm2) kullanılarak standart perforasyon oluşturuldu. Deney grubunda perforasyon fasya ve yağ dokusuyla kapatıldı. Kontrol grubuna herhangibir prosedür uygulanmadı. Dört hafta sonra tavşanlar sakrifiye edildi. Dijital değerlendirme için kartilaj septum çıkarıldı.Örnekler fotoğraflandı ve perforasyon alanları fotğraf analiz programı kullanılarak hesaplandı. Perforasyon alanındaki ortalama küçülme yönünden gruplar karşılaştırıldı. Bulgular: Çalışma periyodunun sonunda ortalama perforasyon alanı çalışma grubunda 1.35±0.51 mm2 iken kontrol grubunda 4.81±0.49 mm2 idi(P
Fascia and Fat Tissue Usage in Nasal Septal Perforation Repair: Experimental Rabbit Model
Purpose: The objective of this study is to present a new method in septum perforation repair.Methods: In this study, 12 New Zealand White mature rabbits were used. The rabbits are dividedinto two groups equally. In all rabbits, a standard perforation was operated on nasal septum byusing a 4mm-diamater punch(12.983 mm2). In the experiment group, the perforations wereclosed by fascia and fat tissue. Any procedure was not implemented in the control group.Rabbits were sacrified 4 weeks later. Cartilaginous septums were removed for digital evaluation.Samples were photographed and perforation areas were calculated by using photograph analyzeprogram. Mean decrease in perforation size between the groups were compared.Results: At the end of the study period the mean perforation area in study group was 1.35±0.51mm2 and in control group was 4.81±0.49 mm2 (P
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- Watson D, Barkdull G. Surgical management of the septal perfo-
ration. Otolaryngol Clin N Am. 2009;42:483-93
- Kazkayasi M, Yalcinozan ET. Uncinate process in the repair of
nasoseptal perforation. Aesth Plast Surg. 2011;35:878-81
- Re M, Paolucci L, Romeo R, Mallardi V. Surgical treatment of nasal
septal perforations. Acta Otorhinolaryngol Ital. 2006;26:102-9
- Pedroza F, Patrocinio LG, Arevalo O. A review of 25-year
experience of nasal septal perforation repair. Arch Facial Plast
Surg.2007;9:12-8
- Friedman M, Ibrahim H, Ramakrishnan V. Inferior turbinate flap
for repair of nasal septal perforation. Laryngoscope 2003;113:1425-8
- Tardy ME. Practical suggestions on facial plastic surgery-how I do
it. Sublabial mucosal flap: repair of septal perforations. Laryngo-
scope.1977;87:275-8
- Pribaz J, Stephens W, Crespo L, Gifford G. New intraoral flap:
facial artery musculomucosal(FAMM) flap. Plast Reconstr Surg.
1992;90:421-9
- Mobley SR, Boyd JB, Astor FC. Repair of a large septal perfora-tion with a radial forearm free flap: brief report of a case. Ear Nose
Throat J.2001;80:512
- Yenigün A, Meric A, Verim A, Ozucer B, Yasar H, Ozkul MH. Septal
perforation repair: mucosal regeneration technique. Eur Arch
Otorhinolaryngol 2012;269:2505-10
- Schutz-Coulon HJ. Three-layer repair of nasoseptal defects.
Otolaryngol Head Neck Surg. 2005;132:213-8
- Ismail HK. Closure of septal perforations. A new technique. J
Laryngol Otol 1964;78:620-3
- Hussain A, Murthy PJ. Modified tragal cartilage-temporoparietal
and deep temporal fascia sandwich graft technique for repair of
nasal septal perforations. J Laryngol Otol.1997;111:435-7
- Hussain A, Kay N. Tragal cartilage inferior turbinate mucoperios-
teal sandwich graft technique for repair of nasal septal perforations.
J Laryngol Otol.1992;106:893-5
- Toyserkani NM, Christensen ML, Skeikh SP, Sorensen
JA.Adipose-derived stem cells new treatment for healing. Ann Plast
Surg.2015;75(1):117-23
- Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue:an underap-
preciated sourceof stem cells for biotechnology. Trends Biotechnol.
2006;24:150-4
- Cai L, Johnstone BH, Cook TG, Liang Z, Traktuev D, Cornetta K
et al. Suppression of hepatocyte growth factor production impairs
the ability of adipose-derived stem cells to promote ischemic tissue
revascularization. Stem Cells. 2007;25:3234-43
- Kim WS, Park BS, Sung JH. The wound healing and anti-
oxidant effects of adipose-derived stem cells. Expert Opin Biol
Ther.2009;9:879-87
- Swibel Rosenthal LH, Benninger MS, Stone CH, Zacharek MA.
Wound healing in the rabbit paranasal sinuses after Coblation :
evaluation for use in endoscopic sinüs surgery. Am J Rhinol Al-
lergy.2009;23:360-3
- Swibel-Rosenthal LH, Benninger MS, Stone CH, Zacharek MA.
Wound healing in the paranasal sinuses after Coblation, Part: II
evaluation for endoscopic sinüs surgery using a sheep model. Am J
Rhinol Allergy.2010;24:464-6
- De Gabory L, Delmond S, Deminiere C, Stoll D, Bordenave L,
Fricain JC. Assessment of biphasic calcium phosphate to repair nasal
septum defects in sheep Plast Reconstr Surg.2011;127:107
- Martinez Neto EE, Dolci JE. Nasal septal perforation closure with
bacterial cellulose in rabbits. Braz J Otorhinolaryngol. 2010;76:442-9