MULTİPLE SKLEROZDA OPTİK KOHERENS TOMOGRAFİ İLE RETİNA SİNİR LİFİ TABAKASININ DEĞERLENDİRİLMESİ Evaluation of Retina Nerve Fiber Layer with Optical Coherence Tomography in Multiple Sclerosis
Amaç: Multiple skleroz (MS) hastalarında spektral optik koherens tomografi (OKT) ile retina sinir lifi tabakası(RSLT) kalınlığını
ölçmek ve bu değerlerle hastaların genişletilmiş özürlülük durum ölçeğinin (EDSS) ilişkisini değerlendirmektir.
Gereç ve Yöntem: Bu ileri dönük çalışmada iki grup oluşturuldu. Çalışmaya nöroloji kliniğinde Mc Donald kriterlerine göre
multiple skleroz tanısı konmuş, takip edilen ve aktif hastalığı olmayan 30 hastanın 30 gözü ve 33 sağlıklı kontrol grubunun 33
gözü dahil edildi. Nöroloji kliniğinde multiple skleroz hastalarına genişletilmiş özürlülük durum ölçeğinin testi yapıldı. Tüm
hastalara tam detaylı oftalmolojik muayene yapıldıktan sonra spektral optik koherens tomografi ile temporal,nasal.inferior
ve superior kadranlarda retina sinir lifi tabakası kalınlıkları incelendi. Her iki grupta da oküler patoloji saptanan ve oküler
hastalık hikayesi olan hastalar çalışma dışında bırakıldı.
Sonuçlar: Hasta ve kontrol grubunun yaş ve cinsiyet dağılımı açısından birbirinden farkı yoktu(p
Physical Therapy and Balneotherapy in Elderly Patients with Neck, Low Back and Knee Pain, Retrospective Study
Objective: The aim of this study was to investigate the contribution of balneotherapy to physical therapy in elderly people with neck, low back and knee pain. Materials and methods: In this retrospective study, the records of patients who received physical therapy or physical therapy + balneotherapy between 2013 and 2018 were examined. The data of 482 patients withthe exact evaluation parameters were analyzed among 704 elderly patients. Results: Only 196 patients had physical therapy (group 1). 286 patients underwent both physical therapyand balneotherapy (group 2). The treatment was applied to 173 patients from the neck, 338 patients from the low back and 287 patients from the knee. Some patients received treatment from two regions. In the general evaluation, the Pain Visual Analog Scale (VAS) results in 482 patients and the Health Assessment Questionnaire (HAQ) results in 276 patients, VAS results in 173 patients and HAQ results in 120 patients who received treatment from the neck, VAS results in 338 patients and HAQ results in 238 patients who received treatment from the low back and VAS results in 287 patients and HAQ results in 177 patients who received treatment from the knee results were examined. A statistically significant improvement was found in all outcome measures evaluated after treatment (p<0.001). In Group 2, recovery rates were statistically higher than group 1 (in all parameters p<0.001). Conclusion: At the end of this study, physical therapy combined with balneotherapy in elderly patients suffering from neck, low back and knee pain were found to be more effective on pain and quality of life than on physical therapy alone. Balneotherapy applied to the whole body may increase the effectiveness of physical therapy
___
- 1. Daldal H., Tök Ö. Y., Şengeze N., Koyuncuoğlu H. R., Tök L., Özkaya D. et all Multipl Sklerozda Retina Sinir Lifi Tabakası Kalınlığı. Turkish Journal of Ophthalmology/Turk Oftalmoloji Dergisi. 2011;41(1):1-5.
2. Costello, F., Coupland, S., Hodge, W., Lorello, G. R., Koroluk, J., Pan, Y. I. et all. Quantifying axonal loss after optic neuritis with optical coherence tomography. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 2006; 59(6): 963-969.
3. Schuman, J. S., Pedut-Kloizman, T., Hertzmark, E., Hee, M. R., Wilkins, J. R., Coker, J. G. et all (1996). Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology. 1996; 103(11): 1889-1898.
4. Peresedova, AV., Baidina, EV., Trifonova, OV., Korepina, OS., Gnezditskii, VV., Krotenkova MV. et all. Pathophysiological aspects of the formation of neurological deficit in multiple sclerosis. Neuroscience and Behavioral Physiology. 2009; 39(1): 39-45.
5. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983; 33(11): 1444-1452
6. Papadopoulos, D., Pham-Dinh, D., & Reynolds, R. Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat. Experimental neurology. 2006; 197(2): 373-385.
7. Chen T, Zeng A, Sun W, Mujat M, Boer JF. Spectral domain optical coherence tomography in glaucoma. Int Ophthalmol Clin. 2008 ; 48(4): 29–45.
8. Wojtkowski M, Srinivasan V, Ko T, Fujimoto J, Kowalczyk A, Duker J. Ultrahigh-resolution, high speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Opt. Express. 2004 ;12(11): 2404-22 .
9. Trip, S. A., Schlottmann, P. G., Jones, S. J., Altmann, D. R., Garway‐ Heath, D. F., Thompson, A. J. et all. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Annals of neurology. 2005; 58(3): 383-391.
10. Abalo-Lojo, J. M., Treus, A., Arias, M., Gómez-Ulla, F., & Gonzalez, F. Longitudinal study of retinal nerve fiber layer thickness changes in a multiple sclerosis patients cohort: a long term 5 year follow-up. Multiple sclerosis and related disorders. 2018; 19: 124-128.