Runa KARA ÖZELÇİ, Berna DİLBAZ

KLOMİFEN SİTRATA REZİSTAN OLAN POLİKİSTİK OVER SENDROMLU OLGULARDA KRONİK DÜŞÜK DOZ GONADOTROPİN VE KONVANSİYONEL DOZ GONADOTROPİN TEDAVİ PROTOKOLLERİNİN KARŞILAŞTIRILMASI Comparison of Chronic Low Dose Gonadotropin and Conventional Dose Gonadotropin Treatment Protocols in Patients Who Had Clomiphen

ÖZET Amaç: Anovulatuar polikistik over sendromlu hastalarda kronik düşük doz ve konvansiyonel doz tedavi rejimlerinin etkinliklerinin karşılaştırılması Gereç ve yöntemler: Klomifen sitrata rezistan anovulatuar PCOS tanısı almış olan 50 olgu çalışmaya dahil edildi. Olguların 25 tanesine konvansiyonel stepwise protokol uygulandı ve (Grup 1) olarak adlandırıldı. Diğer 25 olgudan oluşan gruba (Grup 2)’ da kronik düşük doz FSH protokol uygulandı. Hastalar seri ultrasonografi ve serum estradiol sevilerine bakılarak monitörize edildi. Folliküler gelişim paterni, toplam kullanılan FSH dozu, serum estradiol konsantrasyonu, siklus fekunditesi, multiple gebelik oranları ve ovarian hiperstimulasyon sendromu açısından iki grup karşılaştırıldı. Bulgular: Her iki grup yaş, infertilite süresi, vücut kitle indeksi ve endokrin parametreler açısından benzer olarak bulundu. Stimulasyon süresi Grup 2 'de anlamlı olarak uzun bulundu (p=0.02). Gruplar, ovulatuar siklus açısından değerlendirildiğinde düşük doz kullanılan grupta ovulatuar siklus oranı %68 iken konvansiyonel grupta %76 olarak bulundu. Gebelik oranları açısından değerlendirildiğinde düşük doz grupta gebelik oranı %24 iken konvansiyonel grupta %20 olarak bulundu. Düşük doz kullanılan grupta ovulatuar siklus başına gebelik oranı konvansiyonel gruptan daha yüksek (%37 vs %26) idi. Monofolliküler gelişim düşük doz kullanılan grupta %60, konvansiyonel grupta ise %48 olarak bulundu. Düşük doz kullanılan grupta gerek OHSS (p

Anahtar Kelimeler:

KLOMİFEN SİTRATA REZİSTAN OLAN POLİKİSTİK OVER SENDROMLU OLGULARDA KRONİK DÜŞÜK DOZ GONADOTROPİN VE KONVANSİYONEL DOZ GONADOTROPİN TEDAVİ PROTOKOLLERİNİN KARŞILAŞTIRILMASI Comparison of Chronic Low Dose Gonadotropin and Conventional Dose Gonadotropin Treatment Protocols in Patients Who Had Clomiphene Citrate-Resistant Anovulation Associated With Polycystic Ovarian Syndrome

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