Eosinophilic Pleuropericardial Effusion due to Valproic Acid

Valproic acid is widely used in the treatment of many diseases. It has common side effects such as nausea, vomiting, diarrhea, dizziness, tremor, hair loss, thrombocytopenia. Valproic acid can rarely cause eosinophilic pleuropericardial effusion. Case report; a 31-year-old male patient who had been using valproic acid since childhood due to epilepsy presented with respiratory distress. Eosinophilic pleuropericardial effusion was detected in the examinations performed in the patient with progressive respiratory distress. After excluding other etiological causes, this condition is assumed to be related to valproic acid. Drug changes were made. The end of six months, was observed to be completely cured. Conclusion: This adverse is generally thought to result from drug hypersensitivity reaction. But it is seen that it is an important factor in drug dosage.

Keywords:

Valproic acid, Pleuropericardial effusion Epilepsy, Eosinophilia,

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