Hypoglycemic activity of a dietary mushroom Pleurotus florida on alloxan induced diabetic rats

Species of Pleurotus possess various medicinal properties including hypoglycemic and hypocholesterolemic activities. The feeding effect of the mushroom Pleurotus florida in powdered form was evaluated on growth, blood glucose and cholesterol level in alloxan-induced diabetic albino rats against control. The starch was estimated in dry mushroom and found to be 0.28% (dry weight). The result indicated no significant difference in respect of gaining body weights between Bengal gram-fed and mushroom-fed groups. For studying antidiabetic effect, the control group and half of alloxan-induced (100 mg/kg i.p) experimental groups were fed on normal diet with Bengal gram whereas the other half of alloxan-induced group was fed on same diet but with additional mushroom powder. Blood samples were analysed for glucose, serum cholesterol, triglycerides and uric acid levels on 7th, 14th, 21st and 28th days of alloxan treatment. Body weights and mortality were noted during the period of study. The diabetic group administered with mushroom diet showed significantly decreased level of blood glucose and cholesterol compared to the counterpart. Estimation of lipid profile revealed much lower LDL cholesterol in mushroom fed diabetic group than in non- mushroom fed diabetic control group. The study, thus, points out the prominent effect of feeding dried mushroom (P. florida) on growth of albino rat and positive effect of P. florida on lowering blood glucose and cholesterol level in diabetic rats thereby suggesting its hypoglycemic and hypocholesterolemic effect.

Species of Pleurotus possess various medicinal properties including hypoglycemic and hypocholesterolemic activities. The feeding effect of the mushroom Pleurotus florida in powdered form was evaluated on growth, blood glucose and cholesterol level in alloxan-induced diabetic albino rats against control. The starch was estimated in dry mushroom and found to be 0.28% (dry weight). The result indicated no significant difference in respect of gaining body weights between Bengal gram-fed and mushroom-fed groups. For studying antidiabetic effect, the control group and half of alloxan-induced (100 mg/kg i.p) experimental groups were fed on normal diet with Bengal gram whereas the other half of alloxan-induced group was fed on same diet but with additional mushroom powder. Blood samples were analysed for glucose, serum cholesterol, triglycerides and uric acid levels on 7th, 14th, 21st and 28th days of alloxan treatment. Body weights and mortality were noted during the period of study. The diabetic group administered with mushroom diet showed significantly decreased level of blood glucose and cholesterol compared to the counterpart. Estimation of lipid profile revealed much lower LDL cholesterol in mushroom fed diabetic group than in non- mushroom fed diabetic control group. The study, thus, points out the prominent effect of feeding dried mushroom (P. florida) on growth of albino rat and positive effect of P. florida on lowering blood glucose and cholesterol level in diabetic rats thereby suggesting its hypoglycemic and hypocholesterolemic effect.

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