An Overview of COVID-19 Medicines in Current Guidelines

An acute respiratory disease caused by a new coronavirus (Severe acute respirotary syndrome-coronavirüs-2, previously known as 2019-nCoV), coronavirus disease 2019 (COVID-19), appeared in December 2019 and then has spread rapidly throughout the world starting from China, Japan and South Korea. As of January 30, 2020, the World Health Organization has officially declared the COVID-19 outbreak. Considering the clinical symptoms of COVID-19, it has many symptoms such as high fever, cough, and fatigue. It is reported that this disease is very severe and causes serious consequences such as cytokine storm and acute respiratory distress syndrome in the elderly and those with chronic diseases. Currently, scientists are trying to find a specific antiviral treatment strategy. Various medications such as hydroxychloroquine, lopinavir/ ritonavir, ribavirin, remdesivir and favipiravir are currently being applied in clinical trials to test their efficacy and safety worldwide in COVID-19 treatment, and some promising results have been achieved so far. In this review, agents with potential efficacy against COVID-19 are presented in summary.

Güncel Kılavuzlardaki COVİD-19 İlaçlarına Bir Bakış

Yeni bir koronavirüsün (daha önce 2019-nCoV olarak bilinen Şiddetli akut solunum enfeksiyonu-koronavirüs-2) neden olduğu akut solunum yolu hastalığı, koronavirüs hastalığı 2019 (COVİD-19) Aralık 2019’da ortaya çıkmış ve daha sonra Çin, Japonya ve Güney Kore’den başlayarak Dünya genelinde hızlı bir yayılım göstermiştir. 30 Ocak 2020 itibariyle de Dünya Sağlık Örgütü COVİD-19 salgınını resmi olarak ilan etmiştir. COVİD-19’un klinik semptomlarına bakıldığında yüksek ateş, öksürük, yorgunluk gibi birçok semptomu vardır. Yaşlılarda ve kronik hastalıkları olanlarda bu hastalığın çok ağır geçtiği ve sitokin fırtınası ile akut solunum sıkıntısı sendromu (ARDS) gibi ciddi sonuçlara neden olduğu bildirilmektedir. Şu anda bilim insanları tarafından spesifik antiviral tedavi stratejisi bulunmaya çalışılmaktadır. Hidroksiklorokin, lopinavir/ritonavir, ribavirin, remdesivir ve favipiravir gibi çeşitli ilaçlar şu anda Dünya çapında COVİD-19 tedavisinde etkinliklerini ve güvenliklerini test etmek için klinik çalışmalarda uygulanmaktadır ve şimdiye kadar bazı umut verici sonuçlar elde edilmiştir. Bu derlemede, COVİD-19’a karşı potansiyel etkinliği olan ajanlar özet halinde sunulmaktadır.

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Kaynak Göster

Bezmiâlem Science
  • ISSN: 2148-2373
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2013
  • Yayıncı: Galenos Yayınevi

12.9b5.3b

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