Evaluation of Neutrophil-Lymphocyte Ratios, Mean Platelet Volumes, and Platelet-Lymphocyte Ratios in Pterygium

Objectives: To assess the neutrophil-to-lymphocyte ratio (NLR), mean platelet volumes (MPV), platelet–lymphocyte ratios (PLR) and other complete blood count parameters (CBC) as indicators of inflammation in patients with pterygium. Methods: This study was carried out retrospectively in 111 consecutive pterygium patients and 106 control subjects. Laboratory and clinical parameters were obtained from the patient data management system. NLR and PLR were calculated by dividing neutrophil and platelet count by lymphocyte count. Results: A significant difference was found in NLR and lymphocyte values between the pterygium and control groups (p0.05). Conclusion: NLR may have an association with pterygium, which should be investigated at larger subgroups in further studies. Keywords: Inflammation, mean platelet volume, neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, pterygium

Kaynakça

1. Han SB, Jeon HS, Kim M, Lee SJ, Yang HK, Hwang JM, et al. Risk Factors for Recurrence After Pterygium Surgery: An Image Analysis Study. Cornea 2016;35:1097–103.

2. Liu L, Wu J, Geng J, Yuan Z, Huang D. Geographical prevalence and risk factors for pterygium: a systematic review and meta- analysis. BMJ Open 2013;3:e003787.

3. Chen J, Maqsood S, Kaye S, Tey A, Ahmad S. Pterygium: are we any closer to the cause? Br J Ophthalmol 2014;98:423–4.

4. Namikawa T, Munekage E, Munekage M, Shiga M, Maeda H, Kitagawa H, et al. [The Clinical Role of the Neutrophil/Lymphocyte Ratio in Patients with Advanced Gastric Cancer Treated with Protein-Bound Polysaccharide K and Chemotherapy]. [Article in Japanese]. Gan To Kagaku Ryoho 2015;42:2081–3.

5. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2.

6. Na N, Yao J, Cheng C, Huang Z, Hong L, Li H, et al. Meta-analysis of the efficacy of the pretreatment neutrophil-to-lymphocyte ratio as a predictor of prognosis in renal carcinoma patients receiving tyrosine kinase inhibitors. Oncotarget 2016;7:44039–46.

7. Brooks SD, Spears C, Cummings C, VanGilder RL, Stinehart KR, Gutmann L, et al. Admission neutrophil-lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy. J Neurointerv Surg 2014;6:578–83.

8. Murat SN, Duran M, Kalay N, Gunebakmaz O, Akpek M, Doger C, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology 2013;64:131–6.

9. Fan Z, Zhang Y, Pan J, Wang S. Acute Appendicitis and Mean Platelet Volume: A Systemic Review and Meta-analysis. Ann Clin Lab Sci 2017;47:768–72.

10. Peng YF, Huang YX, Wei YS. Altered mean platelet volume in patients with polymyositis and its association with disease severity. Braz J Med Biol Res 2016;49:e5168.

11. Zheng X, Hao R, Wang Y. [Analysis the relationship of mean platelet volume and nasal obstructive disease]. [Article in Chinese]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2014;28:1662–4.

12. Shi X, Li WC, Mo LJ, Li XH, Luo YZ, Qin LQ, et al. Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity. Ann Clin Biochem 2018;55:368–72.

13. Di Girolamo N, Wakefield D, Coroneo MT. UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci 2006;47:2430–7.

14. Kurt A, Kılıç R, Tad M, Polat OA. YKL-40 expression in pterygium: a potential role in the pathogenesis. International ophthalmology. Int Ophthalmol 2019;39:1445–50.

15. Bradley JC, Yang W, Bradley RH, Reid TW, Schwab IR. The science of pterygia. Br J Ophthalmol 2010;94:815–20.

16. Anguria P, Carmichael T, Ntuli S, Kitinya J. Chronic inflammatory cells and damaged limbal cells in pterygium. Afr Health Sci 2013;13:725–30.

17. Deng M, Ma X, Liang X, Zhu C, Wang M. Are pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio useful in predicting the outcomes of patients with small-cell lung cancer? Oncotarget 2017;8:37200–7.

18. Min K, Kwon S, Cho SY, Choi WJ, Park SU, Jung WS, et al. Atrial Fibrillation is Strongly Associated With the Neutrophil to Lymphocyte Ratio in Acute Ischemic Stroke Patients: A Retrospective Study. J Clin Lab Anal 2017;31.

19. Ilhan N, Daglioglu MC, Ilhan O, Coskun M, Tuzcu EA, Kahraman H, et al. Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration. Ocul Immunol Inflamm 2015;23:287–90.

20. Ozturk C, Balta S, Balta I, Demirkol S, Celik T, Turker T, et al. Neutrophil-lymphocyte ratio and carotid-intima media thickness in patients with Behcet disease without cardiovascular involvement. Angiology 2015;66:291–6.

21. Celik T. Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Dry Eye Disease. Ocul Immunol Inflamm 2018;26:1219–22.

22. Sekeryapan B, Uzun F, Buyuktarakci S, Bulut A, Oner V. Neutrophil- to-Lymphocyte Ratio Increases in Patients With Dry Eye. Cornea 2016;35:983–6.

23. Dursun A, Ozturk S, Yucel H, Ozec AV, Dursun FG, Toker MI, et al. Association of neutrophil/lymphocyte ratio and retinal vein occlusion. Eur J Ophthalmol 2015;25:343–6.

24. Balta S. Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, and Long-Term Major Cardiovascular Events. Angiology 2019;70:289–90.

25. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost 2004;10:175–8.

26. Kim KW, Park SH, Kim JC. Fibroblast biology in pterygia. Exp Eye Res 2016;142:32–9.

27. Strauchen JA, Alston W, Anderson J, Gustafson Z, Fajardo LF. Inaccuracy in automated measurement of hematocrit and corpuscular indices in the presence of severe hyperglycemia. Blood 1981;57:1065–7

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