Mehmet YILDIZ, Teoman ERDEM, Vildan ERDEM

The evaluation of saliva flow rate, pH, buffer capacity, microbiological content and indice of decayed, missing and filled teeth in Behçet’s patients

Background: Several lines of evidence indicate that oral microbial flora play a critical role in the pathogenesis of Behçet disease. Saliva flow rate, buffer capacity and microorganism content are very important in the maintenance of oral health. Aims: We aimed to evaluate saliva flow rate, pH, buffer capacity and Streptococcus mutans and Lactobacilli content along with the decayed, missing, and filled tooth index in Behçet’s patients. Study Design: Case-control study Methods: Forty patients with active Behçet disease [female:male (F/M) 21/19, mean age 31.05±11.08 years] and forty healthy persons (F/M 21/19, mean age 31.03±9.14 years) were included in the study. The oral region was first examined, and the decayed, missing, and filled tooth index was calculated for each person. Stimulated saliva was collected and divided into two separate millimetric tubes to calculate the buffer capacity of the saliva, determine Streptococcus mutans and Lactobacilli levels and measure the pH of the saliva. A Caries Risk Test buffer strip was used to calculate the buffer capacity. Caries Risk Test bacterial kit was used to determine Streptococcus mutans and lactobacilli levels. A pH meter was used to measure the pH of the saliva. Results: The mean saliva pH of the patients was higher than the controls (7.76±0.51, 7.18±0.46, respectively) (p

PDF

___

1. Behçet H. Uber rezidivivierende aphthose, durch ein virus ver- ursachte geschwure am mund, am auge und anden genitalien. Dermatol Wochenschr 1937;105:1152-7.
2. Isogai E, Ohno S, Kotake S, Isogai H, Tsurumizu T, Fujii N, et al. Chemiluminescence of neutrophils from patients with Behcet’s disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Arch Oral Biol 1990;35:43-8. [CrossRef]
3. Mizushima Y, Matsuda T, Hoshl K, Ohno S. Induction of Behçet’s disease symptoms after dental treatment and streptococcal antigen skin test. J Rheumatol 1988;15:1029-30.
4. Yoshikawa K, Kotake S, Sasamoto Y, Ohno S, Matsuda H. Close association of Streptococcus sanguis and Behcet’s disease. Nippon Ganka Gakkai Zasshi 1991;95:1261-7.
5. Mizushima Y. Behçet’s Disease Research Committee of Japan. Skin hypersensitivity of streptococcal antigens and the induction of systemic symptoms by the antigens in Behcet disease. J Rheumatol 1989;16:506-11.
6. Mizushima Y, Matsuda T, Hoshl K, Ohno S. Induction of Behcet’s disease symptoms after dental treatment and streptococcal antigen skin test. J Rheumatol 1988;15:1029-30.
7. Lehner T. The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behçet’s disease. Int Rev Immunol 1997;14:21-32. [CrossRef]
8. Kaneko F, Oyama N, Nishibu A. Streptococcal infection in the pathogenesis of Behçet’s disease and clinical effects of minocycline on the disease symptoms. Yonsei Med J 1997;38:444-54.
9. Calgüneri M, Ertenli I, Kiraz S, Erman M, Celik I. Effect of pro- phylactic benzathine penicillin on mucocutaneous symptoms of Behçet’s disease. Dermatology 1996;192:125-8. [CrossRef]
10. Çelenligil-Nazliel H, Kansu E, Ebersole JL. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet’s disease. J Periodontol 1999;70:1449-56. [CrossRef]
11. Carl W, Havens J, Kielich M. Behcet’s disease: dental and oral soft tissue complications. Quintessence Int 2000;31:113-6.
12. Yosipovitch G, Kaplan I, Calderon S, David M, Chan YH, Weinberger A. Distribution of mucosal pH on the bucca, tongue, lips and palate. A study in healthy volunteers and patients with lichen planus, Behcet’s disease and burning mouth syndrome. Acta Derm Venereol 2001;81:178-80. [CrossRef]
13. Humphrey SP, Williamson RT. A review of saliva: Normal composition, flow, and function. J Prosthet Dent 2001;85:162-9. [CrossRef]
14. International Study Group for Behçet’s Disease. Criteria for diagnosis of Behçet’s disease. Lancet 1990;335:1078-80.
15. Tojo M, Yanagihori H, Zheng X, et al. Bes-1 DNA fragment encoding streptococcal antigen in skin lesions from patients with Behçet’s disease. J Appl Res 2003;3:232-8.
16. Sreebny LM. Saliva: Its role in health and disease. Int Dent Res 1992;42:287-304.
17. Scott J. Structure and function in aging human salivary glands. Gerodontol 1987;5:149-58. [CrossRef]
18. Sreebny LM. Saliva in health and disease: an apprasial and update. Int Dent Res 2000;50:140-61. [CrossRef]
19. Şengün A, Duran İ, Botsalı HE, Dönmez N. Behçet hastalığı olan kişilerde tükürük pH’sı, tamponlama kapasitesi ve çürük insidansının değerlendirilmesi. SÜ Diş Hek Fak Derg 2008;17:1-5.
20. Feslihan Ş. Behçet hastalığında oral ülserasyona eşlik eden bazı tükürük ve serum bileşenlerinin incelenmesi. Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Oral Biyoloji, Yüksek Lisans Tezi, İstanbul, 2003.
21. Mumcu G, Ergun T, Inanc N, Fresko I, Atalay T, Hayran O, et al. Oral health is impaired in Behçet’s disease and is associated with disease severity. Rheumatology (Oxford) 2004;43:1028-33. [CrossRef]
22. Karacayli U, Mumcu G, Simsek I, Pay S, Kose O, Erdem H, et al.The close association between dental and periodontal treatments and oral ulcer course in behcet’s disease: a prospective clinical study. J Oral Pathol Med 2009;38:410-5. [CrossRef]
23. Akman A, Kacaroglu H, Donmez L, Bacanli A, Alpsoy E. Relationship between periodontal findings and Behçet’s disease: a controlled study. J Clin Periodontol 2007;34:85-91. [CrossRef]
24. Mumcu G, Niazi S, Stewart J, Hagi-Pavli E, Gokani B, Seoudi N, et al. Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet’s disease. J Oral Pathol Med 2009;38:406-9. [CrossRef]
25. Hirohata S, Kikuchi H. Behçet’s disease. Arthritis Res Ther 2003;5:139-46. [CrossRef]
26. Mumcu G, Inanc N, Aydin SZ, Ergun T, Direskeneli H. Association of salivary S. mutans colonisation and mannose-binding lectin deficiency with gender in Behçet’s disease. Clin Exp Rheumatol 2009;27(2 Suppl 53):S32-6.
27. Direskeneli H. Behçet’s disease: İnfectious etiology, new autoantigens, and HLA-B51. Annals of Rheumatic Disease 2001;90:996-1002. [CrossRef]
28. Pervin K, Childerstone A, Shinnick T, Mizushima Y, van der Zee R, Hasan A, et al. T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behçet’s disease. J Immunol 1993;151:2273-82.