Ahmet Emre YENİPAZAR, Neşe EKİNCİ, Fulya ÇAKALAĞAOĞLU, Demet ETİT, Haldun KAR

Extra-Gastrointestinal Stromal Tumor of Prostate

Background: Extra-gastrointestinal stromal tumor is defined as a mesenchymal neoplasm arising from soft tissues outside the gastrointestinal tract. Prostatic extragastrointestinal stromal tumor has rarely been noted. Case Report: A 56 year-old man presented with pain in the anal region. A digital rectal examination revealed that the prostate was markedly enlarged with a smooth, bulging surface. Computerized tomography images showed a 6 cm heterogeneous, infiltrative tumor within the prostate gland extending to the trigon of the bladder, left seminal vesicle and rectum. The tru-cut biopsy of the prostate was reported as leiomyoma. It was decided to perform surgery and the masses were easily and completely removed from the adjacent structures. The case was reported as extra-gastrointestinal stromal tumor within the intermediate- risk category with free surgical margins. Four years after the surgery, a locoregional failure was observed and treated with imatinib. Conclusion: Stromal tumor, although rare, should be considered in the differential diagnosis in patients with an enlarged prostate.

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1. Ou Z, Cao Z, He Y, Tang D. Diagnosis and multimodal therapy for extragastrointestinal stromal tumor of the prostate: A case report. Exp Ther Med 2013;6:378-380.
2. Fry CH. Interstitial cells in the urinary tract, where are they and what do they do? BJU Int 2014;114:434-5.
3. Zhang ZH, Feng GW, Liu ZF, Qiao L, Zhang T, Gao C, et al. A young man with primary prostatic extra-gastrointestinal stromal tumor: a rare case report and review of the literature. Int J Clin Exp Pathol 2014;15:1764-70.
4. Lee CH, Lin YH, Lin HY, Lee CM, Chu JS. Gastrointestinal stromal tumor of the prostate: a case report and literature review. Hum Pathol 2006;37:1361-5.
5. Van Der Aa F, Sciot R, Blyweert W, Ost D, Van Poppel H, Van Oosterom A, et al. Gastrointestinal stromal tumor of the prostate. Urology 2005;65:388.
6. Miettinen M, Sobin LH and Lasota J. Gastrointestinal stromal tumors presenting as omental masses--a clinicopathologic analysis of 95 cases. Am J Surg Pathol 2009;33:1267-75.
7. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol 2000;13:577-85.
8. Kim HH, Koh YS, Park EK, Seoung JS, Hur YH, Kim JC et al. Primary extragastrointestinal stromal tumor arising in the pancreas: report of a case. Surg Today 2012;42:386-90.
9. Lasota J, Carlson JA and Miettinen M. Spindle cell tumor of urinary bladder serosa with phe-notypic and genotypic features of gastrointestinal stromal tumor. Arch Pathol Lab Med 2000;124:894-7.
10. Song W, Yang JR, Wang YH and Liang QC. Primary extragastrointestinal stromal tumor of the seminal vesicles. Urology 2012;79:36-7.
11. Yinghao S, Bo Y, Xiaofeng G. Extragastrointestinal stromal tumor possibly originating from the prostate. Int J Urol 2007;14:869-71.
12. Liu S, Yu Q, Han W, Qi L, Zu X, Zeng F, et al. Primary gastrointestinal stromal tumor of the prostate: A case report and literature review. Oncol Lett 2014;7:1925-9.
13. Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer 2002;38:39-51.
14. Robb WB, Bruyere E, Amielh D, Vinatier E, Mabrut JY, Perniceni T, et al; FREGAT Working Group-FRENCH. Esophageal gastrointestinal stromal tumor: is tumoral enucleation a viable therapeutic option? Ann Surg 2015:261:117-24.
15. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002;33:459-65.