Oğuz CANAN, Zeliha HAYTOĞLU

Bocavirus Viremia and Hepatitis in an Immunocompetent Child

Background: So far, many studies have shown that Human Bocavirus ( HBoV) is the main pathogen of the respiratory tract. Until now, there is no study that proves the association between HBoV and hepatitis. HBoV viremia/DNAemia has been associated closely with acute primary infection and moderate-to-severe illness but, more detailed clinical data about HBoV dissemination are still unavailable. Case Report: Here we report a 2-years-5-months-old girl suffering from respiratory distress and heptitis followed in our intensive care unit. HBoV was detected in our patients nose and throat swabs concurrent with whole blood sample by positive polymerase chain reactions. After a through investigation no causative agent other than HBoV viremia was found. Conclusion: Human Bocavirus viremia with high viral loads may be associated with hepatitis.

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Allander T, Jartti T, Gupta S, Niesters HG, Lehtinen P, Osterback R, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis 2007;44:904-10.
Zhou L, Zheng S, Xiao Q, Ren L, Xie X, Luo J, et al. Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children. BMC Infect Dis 2014;14:424-32.
Bharaj P, Sullender WM, Kabra SK, Broor S. Human bocavirus infection in children with acute respiratory tract infection in India. J Med Virol 2010;82:812-6.
Ahn JG, Choi SY, Kim DS, Kim KH. Human bocavirus isolated from children with acute respiratory tract infections in Korea, 2010-2011. J Med Virol 2014;86:2011-8.
Kleines M, Scheithauer S, Rackowitz A, Ritter K, Häusler M. High prevalance of human bocavirus detected in young children with severe acute lower respiratory tract disease by use of a standard PCR protocol and a novel real-time PCR protocol. J Clin Microbiol 2007;45:1032-4.
Byington CL, Ampfo K, Stockman C, Adler FR, Herbener A, Miller T, et al. Community surveillance of respiratory viruses among families in the Utah Better identification of germs-longitudinal viral epidemiology (BIG- LoVE) study. Clin Infect Dis 2015;61:1217-24.
Mitui MT, Tabib SM, Matsumato T, Khanam W, Ahmed S, Mori D, et al. Detection of human bocavirus in the cerebrospinal fluid of children with encephalitis. Clin Infect Dis 2012;54:964-7.
Ursic T, Steyer A, Kopriva S, Kalan G, Krivec U, Petrovec M. Human Bocavirus as the cause of a life-threatening infection. J Clin Microbiol 2011;49:1179-81.
Kainulainen L, Waris M, Söderlund-Venermo M, Allander T, Hedman K, Ruuskanen O. Hepatitis and human bocavirus primary infection in a child with T-cell deficiency. J Clin Microbiol 2008;46:4104-5.
Christensen A, Nordbo SA, Krokstad S, Rognlien AG, Dollner H. Human bocavirus in children: mono-detection, high viral load and viremia are associated with respiratory tract infection. J Clin Virol 2010;49:158-62.