Prostat Kanserinde Bakır, Berilyum, Bor, Titanyum ve Vanadyum İyonlarının Prognostik Önemi Var mı?

Amaç: Metal maruziyetin ile Prostatik adenokarsinom (PCa) ilişkilendiren birçok epidemiyolojik, klinik ve deneysel çalışma vardır. Bu çalışmada, benign prostat hiperplazisi (BPH) ile farklı histopatolojik grade de PCa ve bazı metal / ametal konsantrasyonları arasındaki ilişki araştırılmıştır. Materyal ve Metod: Bu çalışmaya 71 hasta dahil edildi. Hastaların parafin bloklarından alınan örnekler mikrodalga digestion işlemine tabi tutuldu ve örnekler İndüktif olarak eşleşmiş plazma kütle spektrometresi (ICP-MS) ile platin, talyum, kurşun, molibden, kadmiyum, selenyum77, selenium82, demir, potasyum, lityum, berilyum, bor, sodyum, magnezyum, fosfor, kalsiyum, titanyum, vanadyum, krom, manganez, kobalt, nikel, bakır, çinko, arsenik, stronsiyum, kalay ve antimony seviyeleri analiz edildi. Bulgular SPSS programı ile analiz edildi. Bulgular: BPH ve malign hasta gruplarında prostat dokusundaki metal / ametal düzeyler incelendiğinde istatitksel olarak lityum (p = 0,006), berilyum (p = 0,02), bor (p = 0,001), sodyum ( p = 0.009), magnezyum (p = 0.001), fosfor (p = 0.001), kalsiyum (p = 0.001), titanyum (p = 0.004), vanadyum (p = 0.001), krom (p = 0.04), manganez (p = 0,02), kobalt (p = 0,003), nikel (p = 0,005), bakır (p = 0,019), çinko (p = 0,001), arsenik (p = 0,002), stronsiyum (p = 0,001), kalay (p = 0.002) ve antimon (p = 0.001) bulundu. BPH dokularında berilyum, bor, titanyum ve vanadyum konsantrasyonları en az beş kat daha yüksekti. Gleason prognostik derece gruplamasına göre doku metal / ametal seviyeleri karşılaştırıldığında, doku bakır seviyeleri ile derece arasında anlamlı pozitif korelasyon bulundu (p = 0.02). Sonuç: Bu çalışma, berilyum, bor, titanyum ve vanadyumun iyi huylu prostat hiperplazisinde beş kat veya daha fazla olduğu gösterilmiştir. Ayrıca Bakır konsantrasyonunun artmasıyla histolojik derecenin yükseldiğini göstermiştir. Metal konsantrasyonları PCa da prognoz açısından dikkate alınmalıdır.

Anahtar Kelimeler:

metal, ICP-MS, prostat kanseri, metal, ICP-MS, ametal

Is There A Prognostic Significance For Copper, Beryllium, Boron, Titanium and Vanadium Ions in Prostate Cancer?

Aim: There are several epidemiological, clinical and experimental studies that relate heavy metal exposure to Prostatic adenocarcinoma (PCa). In this study, the relationship between benign prostatic hyperplasia (BPH) and PCa, some metal/nonmetal concentrations at the level of the histopathological diagnosis was investigated. Materials and Methods: Seventy-one patients were included in this study. The samples taken from the paraffin blocks of the patients were subjected to microwave digestion, and the samples were analyzed via Inductively coupled plasma mass spectrometry (ICP-MS) to determine the level of tissue concentrations of platinum, thallium, lead, molybdenum, cadmium, selenium77, selenium82, iron, potassium, lithium, beryllium, boron, sodium, magnesium, phosphorus, calcium, titanium, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, strontium, tin, and antimony. The findings were analyzed with SPSS. Results: When metal/nonmetal levels in prostate tissue were examined in BPH and malignant patient groups, a statistically significant difference was found in the levels of lithium (p=0.006), beryllium (p=0.02), boron (p=0.001), sodium (p=0.009), magnesium (p=0.001), phosphorus (p=0.001), calcium (p=0.001), titanium (p=0.004), vanadium (p=0.001), chromium (p=0.04), manganese (p=0.02), cobalt (p=0.003), nickel (p=0.005), copper (p=0.019), zinc (p=0.001), arsenic (p=0.002),strontium (p=0.001), tin (p=0.002) and antimony (p=0.001). Beryllium, boron, titanium and vanadium concentrations were at least five times higher in BPH tissues. When tissue metal/nonmetal levels were compared according to the new Gleason prognostic grade grouping, a significant positive correlation was found between tissue copper levels and grade (p = 0.02). Conclusion: This study showed that beryllium, boron, titanium, and vanadium are five times or more in benign prostatic hyperplasia. It also showed that the histological grade increased with increasing copper concentration. Metal concentrations should be considered for prognosis in PCa.

Keywords:

prostate cancer, metal, non-metal, ICP-MS,

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