Mean Platelet Volume Values and Its Effects on Prognosis in Patients with Acute Ischemic Stroke

Objective: Stroke is a rapid onset of focal or global loss of cerebral function and is the most common cause of mortality and morbidity in adulthood cancer and heart disease patients. Although it has been reported that mean platelet volume (MPV) values may be an independent risk factor for the severity and prognosis of stroke, the results of previous studies are inconsistent. The aim of the present study was to determine the MPV values of ischemic stroke patients which reflects the activity and function of platelets and to observe its effect on clinical outcomes. Method: Sixty-two acute ischemic stroke patients were recruited for the study. Clinical information, MPV, platelet, white blood cell (WBC) and neutrophil, CRP and troponin-T levels were obtained. Results: The mean ± standard deviation age was 72.4±12.6 years. At the end of the study, 28 patients were discharged and 34 patients passed away. The frequency of bilateral stroke was higher in deceased patients (p=0.005). In addition, platelet counts were significantly higher in discharged patients (p=0.016). At first admission, MPV values were 10.59±1.01 fL in discharged patients and 11.29±1.12 fL in deceased patients (p=0.029). At the end of the study, MPV values were measured as 11.46±1.28 fL in deceased patient sand 10.47±0.74 fL in discharged patients (p0.05). Conclusion: Our study indicated that MPV and platelet levels may be associated with mortality in acute ischemic stroke patients and can be used as prognostic markers.

Akut İskemik İnme Geçiren Hastalarda Ortalama Trombosit Hacmi Değerleri ve Prognoza Etkileri

Amaç: İnme, ani başlangıçlı, fokal veya global serebral fonksiyon kaybıdır ve yetişkin çağ kanserleri ve kalp hastalıklarından sonra en sık mortalite ve morbidite nedenidir. Ortalama trombosit hacmi (MPV) değerlerinin inmenin şiddeti ve prognozu için bağımsız bir risk faktörü olabileceği bildirilmiş olmasına rağmen, önceki çalışmaların sonuçları tutarsızdır. Bu çalışmanın amacı, iskemik inme hastalarında trombositlerin aktivitesini ve fonksiyonunu yansıtan MPV değerlerini belirlemek ve bunun klinik sonuçlar üzerindeki etkisini gözlemlemektir. Yöntem: Altmış iki akut iskemik inme hastası çalışmaya alındı. Klinik bilgi, MPV, trombosit, beyaz kan hücresi (WBC) ve nötrofil, C-reaktif protein (CRP) ve troponin-T düzeyleri elde edildi. Bulgular: Ortalama yaş 72,4±12,6 idi. Çalışmanın sonunda 28 hasta taburcu edildi ve 34 hasta eksitus oldu. Bilateral inme sıklığı ölen hastalarda daha yüksekti (p=0,005). Ayrıca taburcu edilen hastalarda trombosit sayısı anlamlı derecede yüksek bulundu (p=0,016). İlk başvuruda, MPV değerleri taburcu olan hastalarda 10,59±1,01 fL ve ölen hastalarda 11,29±1,12 fL idi (p=0,029). Çalışmanın sonunda ölen hasta gurubunda MPV değerleri 11,46±1,28 fL, taburcu olmuş hastalarda 10,47±0,74 fL olarak ölçülmüştür (p0,05). Sonuç: Çalışmamız MPV ve trombosit seviyelerinin akut iskemik inme hastalarında mortalite ile ilişkili olabileceğini ve prognostik belirteçler olarak kullanılabileceğini göstermiştir

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