Interleukin-6 Levels in the Cervicovaginal Fluid of Pregnant Women and Its Predictive Value in Preterm Delivery

Objective: The aim of this study was to determine interleukin (IL)- 6 levels in the cervicovaginal fluid of pregnant women and its value in predicting preterm delivery. Method: One hundred and eleven pregnant women were retrospectively included in the study. Cervicovaginal secretions for each pregnant woman were obtained with a sterile Dacron swab for IL-6 detection. IL-6 was determined using an enzyme-linked immunosorbent assay method. Results: The mean IL-6 levels were found to be significantly higher in the preterm delivery group (5.84±2.09 pg/mL) than in the term delivery group (2.24±0.77 pg/mL) (p=0.001). Relationships were found between IL-6 levels and the frequency of intra-amniotic infection, preterm birth and the history of previous preterm birth. Conclusion: A strong association was found between increased cervicovaginal fluid IL-6 levels and preterm delivery. Results suggest that measurement of IL-6 levels from cervicovaginal swab samples during pregnancy can be used to identify patients with risk as a predictive biomarker for preterm birth.

Hamile Kadınlarda Servikovajinal Sıvıda İnterlökin-6 Düzeyleri ve Preterm Eylem Prediktivitesi

Amaç: Bu çalışmanın amacı hamile kadınların servikovajinal sıvı örneklerinde interlökin (IL)-6 düzeylerini analiz etmek ve preterm doğum için prediktif rolünü belirlemektir. Yöntem: Çalışmaya 111 gebe kadın retrospektif olarak dahil edildi. Her kadın için servikovajinal sekresyonlar, IL-6 saptaması için steril bir Dacron sürüntüsü ile elde edildi. IL-6, enzime bağlı immünosorbent test yöntemi kullanılarak belirlendi. Bulgular: Ortalama servikovajinal sıvı IL-6 düzeyleri erken doğumgrubunda (5,84±2,09 pg/mL) term dönem doğum grubuna göre (2,24±0,77 pg/mL) anlamlı olarak daha yüksek bulundu (p=0,001). IL-6 ile intra-amniyotik enfeksiyon, preterm doğum ve önceki preterm doğum öyküsü arasında pozitif ilişki saptandı. Sonuç: Artmış servikovajinal sıvı IL-6 düzeyleri ile erken doğum arasında güçlü bir ilişki bulunmuştur. Hamilelik döneminde servikovajinal sıvı IL-6 seviyesinin ölçümü, yüksek riskli kadınların erken doğum eyleminin saptanması için bir öngörücü biyobelirteç olarak kullanılabilir

Kaynakça

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