Varsayılan Mod ve Fronto Parietal Ağlarında Fonksiyonel Bağlanabilirlik ile Cinsiyet Farklılıklarının İncelenmesi

Cinsiyetin beynin anatomisinde, işlevinde ve aynı zamanda insan davranışlarında kritik bir rol oynadığı bilinmektedir. Erkek ve kadın beyinleri arasındaki fonksiyonel bağlantıdaki farklılıkları belirlemek, birçok nörolojik ve psikiyatrik durumun prevelansını ve semptomolojisini açıklamaya yardımcı olacaktır. Dinlenme sırasında beynin görüntülenmesi, fMRG sinyalinde fonksiyonel olarak ilişkili alanlar arasında geçici olarak korelasyona sahip olan spontan düşük frekanslı dalgalanmalar (

Analysis of Gender Differences with Functional Connectivity and Default Mode Network and Fronto-parietal Network

Gender is known to play a critical role in the brain's anatomy, function, and also in human behavior. Identifying differences infunctional connectivity between male and female brains will help explain the prevalence and symptomatology of many neurologicaland psychiatric conditions. Imaging of the brain during rest reveals spontaneous low-frequency fluctuations (

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[1]. Jazin E, Cahill L (2010) Sex differences in molecular neuroscience: From fruit flies to humans. Nat Rev Neurosci 11(1):9–17.
[2]. Cosgrove KP, Mazure CM, Staley JK (2007) Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry 62:847–855.
[3]. Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., ... & Verma, R. (2014). Sex differences in the structural connectome of the human brain. Proceedings of the National Academy of Sciences, 111(2), 823-828.
[4]. Biswal, B. B., Mennes, M., Zuo, X. N., Gohel, S., Kelly, C., Smith, S. M., ... & Dogonowski, A. M. (2010). Toward discovery science of human brain function. Proceedings of the National Academy of Sciences, 107(10), 4734-4739.
[5]. Weissman‐Fogel I, Moayedi M, Taylor KS, Pope G, Davis KD (2010): Cognitive and default‐mode resting state networks: Do male and female brains “rest” differently? Hum Brain Mapp.
[6]. Biswal B Yetkin FZ Haughton VM Hyde JS. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 34:537–541
[7]. Friston, K. J. (1994). Functional and effective connectivity in neuroimaging: a synthesis. Human brain mapping, 2(1‐2), 56-78.
[8]. Gong, G., He, Y., & Evans, A. C. (2011). Brain connectivity: gender makes a difference. The Neuroscientist, 17(5), 575-591.
[9]. Mak, L. E., Minuzzi, L., MacQueen, G., Hall, G., Kennedy, S. H., & Milev, R. (2017). The default mode network in healthy individuals: a systematic review and meta-analysis. Brain connectivity, 7(1), 25-33.
[10]. Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences, 100(1), 253-258.
[11]. Cherkassky, V. L., Kana, R. K., Keller, T. A., & Just, M. A. (2006). Functional connectivity in a baseline resting-state network in autism. Neuroreport, 17(16), 1687-1690.
[12]. Laufs, H., Hamandi, K., Salek‐Haddadi, A., Kleinschmidt, A. K., Duncan, J. S., & Lemieux, L. (2007). Temporal lobe interictal epileptic discharges affect cerebral activity in “default mode” brain regions. Human brain mapping, 28(10), 1023-1032.
[13]. Rombouts, S. A., Barkhof, F., Goekoop, R., Stam, C. J., & Scheltens, P. (2005). Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study. Human brain mapping, 26(4), 231-239.
[14]. Allen, E. A., Erhardt, E. B., Damaraju, E., Gruner, W., Segall, J. M., Silva, R. F., ... & Michael, A. M. (2011). A baseline for the multivariate comparison of resting-state networks. Frontiers in systems neuroscience, 5, 2.
[15]. Dosenbach, N. U., Fair, D. A., Cohen, A. L., Schlaggar, B. L., & Petersen, S. E. (2008). A dual-networks architecture of topdown control. Trends in cognitive sciences, 12(3), 99-105.
[16]. Miller EK, Cohen JD (2001): An integrative theory of prefrontal cortex function. Annu Rev Neurosci 24: 167–202
[17]. Marek, S., & Dosenbach, N. U. (2018). The frontoparietal network: function, electrophysiology, and importance of individual precision mapping. Dialogues in clinical neuroscience, 20(2), 133.
[18]. Sheffield, J. M., Repovs, G., Harms, M. P., Carter, C. S., Gold, J. M., MacDonald III, A. W., ... & Barch, D. M. (2015). Frontoparietal and cingulo-opercular network integrity and cognition in health and schizophrenia. Neuropsychologia, 73, 82-93.
[19]. Cservenka A., Stroup M. L., Etkin A., Nagel B. J. (2015). The effects of age, sex, and hormones on emotional conflict-related brain response during adolescence. Brain Cogn. 99, 135–150. 10.1016/j.bandc.2015.06.002
[20]. [Filippi M, Valsasina P, Misci P, Falini A, Comi G, et al. (2012) The organization of intrinsic brain activity differs between genders: A resting-state fMRI study in a large cohort of young healthy subjects. Hum Brain Mapp34: 1330–1343.].
[21]. Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo‐planar MRI. Magnetic resonance in medicine, 34(4), 537-541.
[22]. Smitha, K. A., Akhil Raja, K., Arun, K. M., Rajesh, P. G., Thomas, B., Kapilamoorthy, T. R., & Kesavadas, C. (2017). Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks. The neuroradiology journal, 30(4), 305-317.
[23]. Whitfield-Gabrieli, S., & Nieto-Castanon, A. (2012). Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain connectivity, 2(3), 125-141.
[24]. Cahill, L. (2006). Why sex matters for neuroscience. Nature reviews neuroscience, 7(6), 477.
[25]. Bluhm, R. L., Osuch, E. A., Lanius, R. A., Boksman, K., Neufeld, R. W., Théberge, J., & Williamson, P. (2008). Default mode network connectivity: effects of age, sex, and analytic approach. Neuroreport, 19(8), 887-891.
[26]. Alarcón, G., Pfeifer, J. H., Fair, D. A., & Nagel, B. J. (2018). Adolescent gender differences in cognitive control performance and functional connectivity between default mode and fronto-parietal networks within a self-referential context. Frontiers in behavioral neuroscience, 12, 73.