Diyabetik Ratların Karaciğer ve Böbrek Dokularındaki Antioksidan Aktivite Üzerine Likopen Uygulamasının Etkileri

Bu çalışmanın amacı, diyabetik ratlarda likopen uygulamasının karaciğer ve böbrek dokusundaki malondialdehit, glutatyon, vitamin A, vitamin E ve katalaz üzerine etkilerini araştırmaktır. Çalışmada kullanılan Wistar cinsi albino erkek ratlar, içlerinden rastgele seçilerek kontrol grubu, diyabet grubu, likopen grubu ve diyabet+likopen grubu olmak üzere 4 farklı gruba ayrıldı. Her grupta 7 adet rat bulunmaktadır. Deneysel diyabet oluşturmak için diyabet grubu ve diyabet+likopen grubundaki ratlara intraperitonel yoldan streptozotosin (45 mg/kg) uygulandı. Diyabet+likopen grubu ile likopen grubundaki ratlara 1 ay boyunca her gün oral yoldan 1 ml likopen (ayçiçeği yağında eritildi) uygulandı. Likopen grubunun karaciğer dokularındaki katalaz düzeyi diğer gruplardan önemli derecede düşük bulundu (P

The Effect of Lycopene Application on the Antioxidant Activity in Liver and Kidney Tissues of Diabetic Rats

The scope of the present study was to determine the effect of lycopene on the activity of malondialdehyde (MDA),glutathione, vitamin A, vitamin E and catalase in liver and kidney tissues of diabetic rats. Wistar albino male rats wererandomly allocated into four groups: control, diabetic, diabetic+lycopene and lycopene group (n=7). Rats in the respectivegroups were treated with intraperitoneal streptozotocin (45 mg/kg) to induce diabetes. Rats in the group lycopene anddiabetic+lycopene were given orally 1 ml lycopene every day for 1 month. Catalase levels in the liver tissues of lycopene groupwas significantly lower than other groups (P

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