Mevlüt Recep PEKCİCİ, Marlen SÜLEYMAN, Koray KOŞMAZ, Mehmet ŞENES, Özlem TANAS IŞIKÇI, Abdullah ŞENLİKÇİ, İknur ALKAN KUSABBİ, Yılmaz ÜNAL, Yusuf Murat BAĞ, Sema HÜCÜMENOĞLU

Rektal yoldan uygulanan Red-Ginseng’in kolorektal anastomoz iyileşmesi üzerinde etkisi var mıdır? Bir deneysel çalışma

Amaç: Red-ginsengin kolon anastomozu iyileşmesindeki olası etkilerini değerlendirmek. Metot: Grup 1’de (sham) laparotomi ve kolonik mobilizasyon yapıldı. Diğer 2 grupta (grup 2+3) kolonik transeksiyon ve anastomoz yapıldı. Grup 2 (kontrol)’de tüm ratlara 10 gün boyunca rektal yoldan 2 ml saline verildi. Grup 3 (ilaç grubu)’de tüm ratlara 10 gün boyunca 2,5 gr/kg ml red ginseng ekstresi verildi. Sonuçlar: Sham grubundaki ratlar en yüksek patlama basıncına sahipti ve red ginseng grubundaki ratlar kontrol grubuna göre daha yüksek patlama basıncına sahipti (p

Does rectal application of Red-Ginseng have an effect on colorectal anastomosis healing? An experimental study

Aim: To evaluate the possible effects of red-ginseng on colon anastomosis healing in an experimental rat model. Methods: In Group 1 (sham), laparotomy and colonic mobilization were performed. Colonic transection and anastomosis were performed to Groups 2 and 3. In Group 2 (control), 2 ml of saline was administered rectally to all rats for 10 days. Group 3 (drug group) rats were given 2.5 gr/kg ml red ginseng extract rectally for 10 days. Results: The rats in the sham group had the highest bursting pressure and the rats in the red ginseng group had higher bursting pressure than in the control group (p

PDF

___

1. Kuru S, Kismet K, Bag YM, Barlas AM, Senes M, Durak M, et. al. Does the application of Ankaferd Blood Stopper rectally have positive effects on the healing of colorectal anastomosis and prevention of anastomotic leakage? An experimental study. Biomed Pharmacother. 2017;96:968-73.
2. Barlas AM, Kuru S, Kismet K, Cavusoglu M, Bag YM, Senes M, et. al. Rectal application of argan oil improves healing of colorectal anastomosis in rats. Acta Cir Bras. 2018;33:565-76.
3. Park GH, Park KY, Cho HI, Lee SM, Han JS, Won CH, et al. Red ginseng extract promotes the hair growth in cultured human hair follicles. J Med Food. 2015;18:354-62.
4. Park KS, Park DH. The effect of Korean Red Ginseng on fullthickness skin wound healing in rats. J Ginseng Res. 2019;43:226-35.
5. Wasowicz W, Nève J, Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 1993;39:2522–6.
6. Hadwan MH. Simple spectrophotometric assay for measuring catalase activity in biological tissues. BMC Biochemistry 2018;19:7.
7. Taylan E, Resmi H. The Analytical Performance of a Microplate Method for Total Sulfhydryl Measurement in Biological Samples. Turkish Journal of Biochemistry 2010;35:275-8.
8. Ehrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg 1969;170:203-6.
9. Philips JD, King CS, Fonkalsrud EW, Zeng H, Dindar H. Effects of chronic corticosteroid and vitamin A on the healing of intestinal anastomoses. Am J Surg 1992;163:71-7.
10. Al-Khayal K, AlWesaimer AS, Abdulla M, Ahmed R. Insulin-like Growth Factor Administration Stimulates Wound Healing on Colonic Anastomosis in Hypoxic Rat Model. Dr. Sulaiman Al Habib Medical Journal 2020;2:43-50.
11. Ekici U, Ferhatoğlu MF, Çitgez B, Uludag M. Effects of the Folk Medicinal Plant Extract Ankaferd BloodStopper on the Healing of Colon Anastomosis: An Experimental Study in a Rat Model. Sisli Etfal Hastan Tip Bul. 2019;53:154-9.
12. Aghayeva A, Benlice C, Bilgin IA, Atukeren P, Dogusoy G, Demir F, et al. The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model. Tumori Journal. 2017;103:307-13.
13. Arapoglou S, Kambaroudis A, Grivas I, Delis GA, Karkos C, Ballas K, et al. The Effect of Iloprost in the Healing of Colonic Anastomosis in Rats under Chemotherapy with Irinotecan. Chirurgia (Bucur). 2017;112:705-13.
14. Ruiz-Luque V, Parra-Membrives P, Escudero-Severín C, Aguilar- Luque J. Effect of Alprostadil on Colorectal Anastomoses Under Relative Ischemia. J Surg Res. 2019;236:230-7.
15. Ferhatoğlu MF, Kıvılcım T, Vural G, Kartal A, Filiz Aİ, Kebudi A, et al. Comparison of the effects of two different marinederived omega-3 fatty acid sources, krill oil, and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model. Ulus Travma Acil Cerrahi Derg. 2019;25:324-30.
16. Bae EA, Hyun YJ, Choo MK, Oh JK, Ryu JH, Kim DH. Protective effect of fermented red ginseng on a transient focal ischemic rats. Arch Pharm Res. 2004;27:1136-40.
17. Durhan A, Koşmaz K, Şenlikci A, Erguder E, Suleyman M, Duymus ME, et al. Does red ginseng ameliorate liver damage caused by obstructive jaundice?: an experimental study. J Health Sci Med 2021;4:233-9.
18. Koşmaz K , Durhan A , Şenlikci A , Suleyman M, Bostanci MT, Pekcici MR, et al. Evaluation of the Protective Effect of Red Ginseng on Lipid Profile, Endothelial and Oxidative Damage after Splenectomy in Rats. ACEM. 2021;6: 43-9.