Mehmet Erman ERDEMLİ, Zeliha SELAMOGLU, Yusuf TÜRKOZ, Zeynep ERDEMLİ, Harika GÖZÜKARA BAG

The effects of acrylamide and vitamin E administration during pregnancy on adults’ ovarian tissue: An experimental study

Aim: The aim of the present study is to investigate the effects on ovarian tissues of adult female rats, which were the offspring ofrats administered acrylamide (AA) and vitamin E during pregnancy.Material and Methods: Thirty rats were divided into 5 groups of 6 pregnant rats, as the Control, Corn Oil, Vitamin E, AA, Vitamin E +AA groups. The births were monitored on the 21st day to select the female rats. The selected female rats were decapitated at the endof the 8th week and their ovarian tissues were removed under anesthesia malondialdehyde (MDA), reduced glutathione (GSH), totalantioxidant capacity (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), catalase (CAT)and nitric oxide (NO) levels were examined.Results: Administration of AA during pregnancy caused an increase in MDA, TOS, OSI and NO levels and a decrease in GSH, SOD, CATand TAS levels in the ovarian tissues of the rats when compared to the control group. It was determined that vitamin E administrationcaused an increase in GSH, SOD, CAT and TAS levels in ovarian tissues, compared to all other groups (P

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