Relationship of neuropathic pain component andosteoarthritis stage in patients with knee osteoarthritis

Aim: The aim of this study was to determine the frequency of neuropathic pain (NP) in patients with knee osteoarthritis (OA) and the relationship between knee OA stage and NP degree.Materials and Methods: This study included 63 patients (11 male, 52 female; mean age 62.4 ± 11.9 years; range 40-89 years) who were diagnosed with knee OA according to the American College of Rheumatology between January and May 2019. For all the participants, the knee pain was evaluated with the Visual Analog Scale (VAS), the functional evaluation was performed through Western Ontario and McMaster University (WOMAC) Osteoarthritis Index, and the neuropathic pain (NP) component was evaluated through Pain-DETECT Questionnaire (PDQ). The Kellgren-Lawrence grading system was used to determine radiological severity.Results: Of the total, 18 patients (28.5%) were classified as possible NP and 15 patients (23.5 %) were classified as likely NP. The symptom durations of the patients with final NP diagnosis were longer (p

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1. Hedbom E, Hauselmann HJ. Molecularaspects of pathogenesis in osteoarthritis: the role of inflammation. Cell Mol Life Sci 2002;59:45-53.
2. Cesare Paul E, Steven B Abramson. Osteoartrit Patogenezi. Kelley Romatol 2006:1493-513.
3. Mease PJ, Hanna S, Frakes EP, et al. Pain mechanisms in osteoarthritis: understanding the role of central pain and current approaches to its treatment. J Rheumatol 2011;38:1546-51.
4. Salaffi F, Ciapetti A, Carotti M. The sources of pain in osteoarthritis: a pathophysiological review. Reumatismo 2014;66:57-71.
5. Fingleton C, Smart K, Moloney N, et al. Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage 2015;23:1043-56
6. French HP, Smart KM, Doyle F. Prevalence of neuropathic pain in knee or hip osteoarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum 2017;47:1-8.
7. Finan PH, Buenaver LF, Bounds SC, et al. Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum 2013;65:363-72.
8. Smith BH, Torrance N, Bennett MI, et al. Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain 2007;23:143-9.
9. Berger A, Toelle T, Sadosky A, et al. Clinical and economic characteristics of patients with painful neuropathic disorders in Germany. Pain Pract 2009;9:8-17.
10. Bouhassira D, Lanteri-Minet M, Attal N, et al. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 2008;136:380-7.
11. Altman RD. Criteria for classification of clinical osteoarthritis. J Rheumatol Suppl 1991;27:10-2.
12. Tuzun EH, Eker L, Aytar A, et al. Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthritis Cartilage 2005;13:28-33.
13. Lequesne MG. The algofunctional indices for hip and knee osteoarthritis. J Rheumatol 1997;24:779-81
14. Alkan H, Ardic F, Erdogan C. Turkish version of the pain-Detect questionnaire in the assessment of neuropathic pain: a validity and reliability study. Pain Med 2013;14:1933-43.
15. Ohtori S, Orita S, Yamashita M, et al. Existence of a neuropathic pain component in patients with osteoarthritis of the knee. Yonsei Med J 2012;53:801- 5.
16. Hochman JR, Gagliese L, Davis AM, et al. Neuropathic pain symptoms in a community knee OA cohort. Osteoarthritis Cartilage 2011;19:647-54.
17. Valdes AM, Suokas AK, Doherty SA, et al. History of knee surgery is associated with higher prevalence of neuropathic pain-like symptoms in patients with severe osteoarthritis of the knee. Semin Arthritis Rheum 2014;43:588-92.
18. Roubille C, Raynauld JP, Abram F, et al. The presence of meniscal lesions is a strong predictor of neuropathic pain in symptomatic knee osteoarthritis: a crosssectional pilot study. Arthritis Res Ther 2014;16:507- 11.
19. Zhang RX, Ren K, Dubner R. Osteoarthritis pain mechanisms: basic studies in animal models. Osteoarthritis Cartilage 2013;21:1308-15.
20. Dimitroulas T, Duarte RV, Behura A, et al. Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment. Semin Arthritis Rheum 2014;44:145-54.
21. Perrot, S. Osteoarthritis pain. Best Pract Res Clin Rheumatol 2015;29:90-7.
22. Polat CS, Dogan A, Ozcan DS, et al. Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis? Arch Rheumatol 2017;32:333-8.
23. Kocyigit BF, Koca TT. Neuropathic pain adversely affects functional status, quality of life and depression in patients with knee osteoarthritis. Ortadogu Tıp Derg 2019;1:15-21.
24. Askin A, Ozkan A, Tosun A, et al. Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain. Kaohsiung J Med Sci 2017;33:152-8.
25. Moss P, Benson HAE, Will R, et al. Patients With Knee Osteoarthritis Who Score Highly on the PainDETECT Questionnaire Present With Multimodality Hyperalgesia, Increased Pain, and Impaired Physical Function. Clin J Pain 2018;34:15-21.