Erdal BENLİ, Ahmet KARATAŞ, Ebru ÇANAKÇI, Tülin BAYRAK, Ahmet BAYRAK, Mürüvvet AKÇAY ÇELİK

Protective effect of ibuprofen against renal ischemiareperfusion injury

Aim: Ibuprofen is an older agent, but its intravenous form is a very new drug. The aim of this study was to investigate whetherintravenous form of ibuprofen has protective effect against renal ischemia reperfusion injury at two different doses such as 10-30mg/kg.Material and Methods: Thirty-two Wistar Albino type female rats were divided into 4 groups as sham, control, IBU-10, IBU-30. In thecontrol group, 60 minutes renal ischemia and 60 minutes reperfusion were performed. In the ibuprofen groups, at the 45th minuteof ischemia, ibuprofen was administered in different doses at 10 mg/kg and 30 mg/kg through intraperitoneally. After 60 minutes ofischemia, the clamps were opened. Renal tissue and blood samples were collected from the rats at the end of the reperfusion period.Serum TAS, TOS and prolidase enzyme levels were analyzed in plasma samples. Both histopathological and biochemical evaluationswere performed with kidney tissue.Results: In the groups given intravenous ibuprofen, less cellular damage was always detected. Cellular damage indicators weresignificantly lower in the treated rats than in the control group. Serum and tissue prolidase values were different between groups(p

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