Is there a predictive association between vitamin D concentrations and lower respiratory tract infections in infants?
Is there a predictive association between vitamin D concentrations and lower respiratory tract infections in infants?
Aim: Vitamin D deficiency have been estimated to be endemic in the worldwide and in each age group and also it is reportedthat vitamin D has important effects on both natural and acquired immunity and there may be a relationship between deficiencyand predisposition to infections The aim of this study is to investigate whether serum vitamin D level are effective in infant lowerrespiratory tract infection which is one of the most mortal infectious diseases in worldwide.Material and Methods: In our study, between October 2016 and January 2018 in Department of Pediatrics, the data of 418 infantswith LRTI and their ages ranging from 5 to 24 months and were examined retrospectively. Vitamin D levels were studied in 106 ofthis patients.Results: In group-1, the mean duration of vitamin D supplementation was 4.9 months, while the mean in group-2 was 8.6 months.Breastfeeding time was 3.27 months in group 1 while it was 5.71 months in group 2. Both the duration of breastfeeding and theduration of vitamin D supplementation were shorter in group 1 than in group 2.Those difference between the groups was in terms ofstatistically significant (p< 0.05)Conclusion: Vitamin D deficiency in infants may be associated with LRTI, and even vitamin D deficiency may be a predisposing factorfor severe LRTIs and also the frequency and severity of LRTIs can be reduced with optimal serum levels of vitamin D.
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- 1. Das RR1, Singh M, Naik SS. Naik, Vitamin D as an adjunct to
antibiotics for the treatment of acute childhood pneumonia.
Cochrane Database Syst Rev 2018;7:Cd011597.
- 2. Li W, Cheng X, Guo L, et al., Association between serum
25-hydroxyvitamin D concentration and pulmonary infection
in children. Medicine (Baltimore) 2018;97:e9060.
- 3. Somnath SH, Biswal N, Chandrasekaran V, et al. Therapeutic
effect of vitamin D in acute lower respiratory infection: A
randomized controlled trial. Clin Nutr ESPEN 2017;20:24-8.
- 4. Ong T, Striegl A, Marshall SG, Respiratory System, Kliegman
RM, Nelson Textbook of Pediatrics, Philadelphia, Elsevier,
2016: p. 1981-2156.
- 5. Gupta P , Dewan P, Shah D, et al., Vitamin D Supplementation
for Treatment and Prevention of Pneumonia in Under-five
Children: A Randomized Double-blind Placebo Controlled
Trial. Indian Pediatr 2016;53:967-76.
- 6. Leis KS, McNally JD, Montgomery MR, et al. (Vitamin D intake
in young children with acute lower respiratory infection).
Zhongguo Dang Dai Er Ke Za Zhi 2012;14:1-6.
- 7. Buchanan AO, Marquez ML, Nutritional Requirements,
Kliegman RM, Nelson Textbook of Pediatrics, Philadelphia,
Elsevier, 2016: p. 268-86.
- 8. Chowdhury R, Taneja S, Bhandari N, et al., Vitamin-D
deficiency predicts infections in young north Indian children:
A secondary data analysis. PLoS One 2017;12:e0170509.
- 9. Binks MJ, Smith-Vaughan HC, Bar-Zeev N, Vitamin D
insufficiency among hospitalised children in the Northern
Territory. J Paediatr Child Health 2014;50:512-8.
- 10. Yakoob MY, Salam RA, Khan FR, Vitamin D supplementation
for preventing infections in children under five years of age.
Cochrane Database Syst Rev 2016;11:Cd008824.
- 11. Oduwole, A.O., Renner J.K., Disu E., Ibitoye E., Emokpae E.
Relationship between vitamin D levels and outcome of
pneumonia in children. West Afr J Med, 2010;29:373-8.
- 12. Buchanan AO, Marquez ML, Feeding Healthy Infants,
Children and Adolescentss, Kliegman RM, Nelson Textbook
of Pediatrics, Philadelphia, Elsevier, 2016: p. 286-95.
- 13. Ren J, Sun B, Miao P, (Correlation between serum vitamin
D level and severity of community acquired pneumonia
in young children). Zhongguo Dang Dai Er Ke Za Zhi
2013;15:519-21.
- 14. Gorman S, Buckley AG, Ling KM, et al, Vitamin D
supplementation of initially vitamin D-deficient mice
diminishes lung inflammation with limited effects on
pulmonary epithelial integrity. Physiol Rep 2017;5:e13371.
- 15. Haugen J, Basnet S, Hardang IM, et al., Vitamin D status
is associated with treatment failure and duration of illness
in Nepalese children with severe pneumonia. Pediatr Res
2017;82:986-93.
- 16. Haider N, Nagi AG, Khan KM. Frequency of nutritional
rickets in children admitted with severe pneumonia. J Pak
Med Assoc 2010;60:729-32.
- 17. Huang Y, Fu L, Yang Y. Age-Related Vitamin D Deficiency
Is Associated with the Immune Response in Children with
Community-Acquired Pneumonia. J Nutr Sci Vitaminol
(Tokyo) 2017;63:1-7.
- 18. Esposito S, Lelii M. Vitamin D and respiratory tract infections
in childhood. BMC Infect Dis 2015;15:487.
- 19. Larkin A, Lassetter J. Vitamin D deficiency and acute
lower respiratory infections in children younger than 5
years: identification and treatment. J Pediatr Health Care
2014;28:572-82.
- 20. Grant CC, Wall CR, Gibbons MJ, et al. Child nutrition and
lower respiratory tract disease burden in New Zealand: a
global context for a national perspective. J Paediatr Child
Health, 2011;47:497-504.