Histopathological features of salivary gland tumors: A single-center experience

Aim: This study’s goal was to retrospectively evaluate cases who were diagnosed with primary salivary gland tumors in our center, to examine the histopathological features of these tumors, and to reveal difficulties in the differential diagnosis. Material and Methods: Sixty-four patients who applied to our center with complaints of pain and swelling in the salivary gland region between January 2016 and February 2020 and who were diagnosed with salivary gland tumor in our pathology clinic were analyzed retrospectively. The age and sex of the patients, the salivary gland where the tumor was located, and the histopathological examination results were recorded. Results: The age range of the patients was 13-89 years, and 57.8% and 42.2% of 64 patients in total were female and male, respectively. While 86% of the patients had tumors located in the parotid gland, 14% of them had tumors located in the submandibular gland. According to the histopathological examination results, 89% and 11% of the patients had benign and malignant tumors, respectively. While the most common tumor among benign tumors was a pleomorphic adenoma at a rate of 57.8%, the most common tumor among malignant tumors was a mucoepidermoid carcinoma at a rate of 4.7%. Conclusion: In the present study, salivary gland tumors were more common in females. The majority of salivary gland tumors were located in the parotid gland, and the majority of them were benign. The majority of tumors located in the submandibular gland were malignant.

PDF

___

1. Boukheris H, Curtis RE, Land CE, et al. Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: A populationbased study in the United States. Cancer Epidemiol Biomarkers Prev 2009;18:2899-906 .
2. Yagiz C, Karaman E. Tükürük bezlerinin selim tümörleri. Türkiye Klinikleri. J Surg Med Sci (Özel sayılar) Kulak Burun Boğaz Dergisi 2007;3:22-6.
3. Wenig BM. Major and minor salivary glands: Neoplasms of the salivary glands, in Wenig BM , Atlas of Head and Neck Pathology. Philadelphia, PA, Elsevier 2008;582-702.
4. Dong C, Hemminki K. Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms. Br J Cancer Suppl 2001;85: 997-1005.
5. Cuhruk C, Yilmaz O. Parotis bezi kitlelerinde tanı yöntemleri. Kulak Burun Boğaz ve Baş Boyun Cerrahisi Dergisi 1993;1:155-8.
6. Banu Atalay, Fatih Bora, Serdar Ceylan, et al. Salivary gland masses: analysis of 158 cases. S.D.Ü. Tıp Fak. Derg 2011;18:82-5.
7. Rice DH. Nonneoplastic diseases of the salivary glands. Otolaryngology.de. Ed. Paparella MM. 3th ed. Volum3. Philadelphia, Saunders Comp 1993;475-86.
8. Duck SW, McConnel FM. Malignant degeneration of pleomorphic adenoma-clinical implications. Am J Otolaryngol 1993;14:175-8.
9. Hicks J, Flaitz C. Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers. Oral Oncol 2000;36:454-60.
10. Tian Z, Li L, Wang L, et al. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 2010;39:235-42.
11. Espinoza S., Felter A., Malinvaud D., et. al. Warthin's tumor of the parotid gland: surgery or follow-up? Diagnostic value of a decisional algorithm with functional MRI.Diagn Interv Imaging 2016;97:37-43.
12. Loyola AM, De Araujo VC, De Sousa SOM, et al. Minor salivary gland tumours. A retrospective study of 164 cases in a Brazilian population. European Journal of Cancer Part B 1995;31:197-201.
13. Arshad AR. Parotid swellings: report of 110 consecutive cases.Med J Malaysia 1998;53: 417-22.
14. Kim KH, Sung MW, Chung PS, et al. Adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 1994;120:721-6.
15. Seifert G. Classification and differential diagnosis of clear and basal cell tumors of the salivary glands. Semin Diagn Pathol 1996;13:95-103.
16. Mino M , Pilch BZ, Faquin WC. Expression of KIT (CD117) in Neoplasms of the Head and Neck: An Ancillary Marker for Adenoid Cystic Carcinoma. Mod Pathol. 2003;16:1224-31.
17. Lewis JE, Olsen KD, Weiland LH. Acinic cell carcinoma clinicopathologic review. Cancer 1991;67:172-9.
18. Sarioglu S, Pabuccuoglu U, Kirimca F, et al. Extensive local invasive epi-myoepithelial carcinoma of the parotid gland. J BUON 1999;4:451-3.
19. John WE, Lester DR. Malignant Neoplasms of the Salivary Glands. Head and Neck Pathology 2 th ed. Elsevier, Philadelphia 2013;267-334.
20. Pelkey TJ, Mills SE. Histological transformation of polymorphous low grade adenocarcinoma of the salivary gland. Am J Clin Pathol 1999;111:785-91.
21. Plambeck K, Friedrich RE, Bahlo M, et al. TNM staging, histopathological grading, and tumor associated antigens in patients with a history of mucoepidermoid carcinomas of the salivary glands. Anticancer Res 1999;19:2397-404.
22. Handra-Luca A. Salivary glands. Primary salivary gland neoplasms – malignant. Pathology Outlinescom, Inc. 2020.