Factors affecting hepatitis B immunization in celiac disease
Factors affecting hepatitis B immunization in celiac disease
Aim: While 90-95% of the adult population responds to hepatitis-B vaccination, it is known that, this rate is lower in patients withCD. In our study, determination of response rates of vaccinated celiac patients, and the affecting factors associated with vaccineresponses were the aims of our investigation.Material and Methods: The study included 280 celiac patients who applied to the polyclinic between 2015-2019 years. Demographic,anthropometric characteristics (age, gender, onset age, disease duration, smoking, body mass index(BMI), waist-hip ratios) andsymptoms in patients were documented. Hepatitis B, C, delta serology were examined. The prevalence of chronic hepatitis andassociated risk factors were evaluated. Hepatitis-B vaccination rates and vaccine responses were determined. The risk factorsassociated with the immune response were reviewed.Results: 212 (75.7%) of the patients were female, the mean-age of the patients was 33.4±10.8 and the disease duration was 4.9±3.7years. In 14 (5%) of the patients there were chronic viral infections, 18 (6.4%) had natural immunity, 92 (32.9%) were immunized,58 (56.4%) were not encountered with viral infection. No significant correlation was found between the presence of chronic viralhepatitis and risk factors. 28 (30.4%) patients who had not vaccine response. It was observed that; the dietary incompatibility andabsence of immunological remission were significantly higher, the BMI and the waist size were significantly lower in non-responsegroup (P
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- 2. Green PH, Cellier C. Celiac disease. N Engl J Med
2007;357:1731-43.
- 3. Plot L, Amital H. Infectious associations of Celiac disease.
Autoimmun Rev 2009;8:316-9.
- 4. Soto SI, Vázquez SR, Ulla JR, et al. Onset of celiac disease
after acute hepatitis B infection. Gastroenterol Hepatol
2010;33:17-20.
- 5. Ahishali E, Boztas G, Akyuz F, et al. Response to hepatitis
B vaccination in patients with celiac disease. Dig Dis Sci
2008;53:2156-9.
- 6. Nemes É, Lefler É, Szegedi L, et al. Gluten intake interferes
with the humoral immune response to recombinant hepatitis
B vaccine in patients with celiac disease. Pediatrics
2008;121:1570-6.
- 7. Toy M, Önder FO, Wörmann T, et al. Age-and region-specific
hepatitis B prevalence in Turkey estimated using generalized
linear mixed models: a systematic review. BMC Infect Dis
2011;11:337.
- 8. Tozun N, Ozdogan O, Cakaloglu Y, et al. Seroprevalence
of hepatitis B and C virus infections and risk factors in
Turkey: a fieldwork TURHEP study. Clin Microbiol Infect
2015;21:1020-6.
- 9. Gamal S, Enan K, Hussien M, et al. Association between
hepatitis B virus and celiac disease patients in Khartoum
state, Sudan. Clin Microbial 2013;2:107.
- 10. Hweta AA, Shagleb AA, Elgadi MO, et al. Anti-Hepatitis B
Antibody status in children with coeliac disease. Ibnosina J
Med Biomed Sci 2018;10:83.
- 11. Rubio-Tapia A, Murray JA. The liver in celiac disease.
Hepatology 2007;46:1650-8.
- 12. Nau AL, Fayad L, Lazzarotto Cet al. Prevalence and clinical
features of celiac disease in patients with hepatitis B
virus infection in Southern Brazil. Rev Soc Bras Med Trop
2013;46:397-402.
- 13. Lemon SM, Thomas DL. Vaccines to prevent viral hepatitis.
N Engl J Med 1997;336:196-204.
- 14. Assad S, Francis A. Over a decade of experience with a yeast
recombinant hepatitis B vaccine. Vaccine 1999;18:57-67.
- 15. Ertem D, Gonen I, Tanidir C, et al. The response to hepatitis B
vaccine: does it differ in celiac disease? Eur J Gastroenterol
Hepatol 2010;22:787-93.
- 16. Ertekin V, Tosun MS, Selimoglu MA. Is there need for a
new hepatitıs B vaccine schedule for children with celiac
disease? Hepat Mon 2011;11:634.
- 17. Leonardi S, Spina M, Spicuzza L, et al. Hepatitis B vaccination
failure in celiac disease: is there a need to reassess current
immunization strategies? Vaccine 2009;27:6030-3.
- 18. Park SD, Markowitz J, Pettei M, et al. Failure to respond to
hepatitis B vaccine in children with celiac disease. J Pediatr
Gastroenterol Nutr 2007;44:431–5.
- 19. Martinetti M, De Silvestri A, Belloni C, et al. Humoral response
to recombinant hepatitis B virus vaccine at birth: role of HLA
and beyond. Clin Immunol 2000;97:234-40.
- 20. Marsh MN. Gluten, major histocompatibility complex,
and the small intestine: a molecular and immunobiologic
approach to the spectrum of gluten sensitivity (‘celiac
sprue’). Gastroenterology 1992;102:330-54.
- 21. Marathe PH, Gao HX, Close KL. American diabetes
association standards of medical care in diabetes 2017. J
Diabetes 2017;9:320-4.
- 22. Bardella MT, Fraquelli M, Quatrini M, et al. Prevalence of
hypertransaminasemia in adult celiac patients and effect of
gluten-free diet. Hepatology 1995;22:833-6.
- 23. Fine KD, Ogunji F, Saloum Y, et al. Celiac sprue: another
autoimmune syndrome associated with hepatitis C. Am J
Gastroenterol 2001;96:138-45.
- 24. Noh KW, Poland GA, Murray JA. Hepatitis B vaccine
nonresponse and celiac disease. Am J Gastroenterol
2003;98:2289-92.
- 25. Zanoni G, Contreas G, Valletta E, et al. Normal or defective
immune response to Hepatitis B vaccine in patients with
diabetes and celiac disease: An open issue. Hum Vaccin
Immunother 2015;11:58-62.
- 26. Filippelli M, Garozzo MT, Capizzi A, et al. Immune response
to hepatitis B virus vaccine in celiac subjects at diagnosis.
World J Hepatol 2016;8:1105.
- 27. Jouneghani AS, Chaleshtori MH, Khoshdel A, et al. Evaluation
of response to hepatitis B vaccine in Iranian 6–18-year-old
students. J Res Med Sci 2017;22:116.
- 28. Yang S, Tian G, Cui Y, et al. Factors influencing immunologic
response to hepatitis B vaccine in adults. Sci Rep
2016;6:27251.
- 29. Meriki HD, Tufon KA, Anong DN, et al. Vaccine uptake and
immune responses to HBV infection amongst vaccinated and
non-vaccinated healthcare workers, household and sexual
contacts to chronically infected HBV individuals in the South
West Region of Cameroon. PloS One 2018;13:0200157.
- 30. Chathuranga L, Noordeen F, Abeykoon A. Immune response
to hepatitis B vaccine in a group of health care workers in Sri
Lanka. Int J Infect Dis 2013;17:1078-9.
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