Evaluation of stroke risk factors and characteristics in the comorbidity of cancer

Evaluation of stroke risk factors and characteristics in the comorbidity of cancer

Aim: Stroke and cancer can be followed together and in the presence of cancer, there may be changes in classical stroke characteristics. The aim of this study was to determine the effect of cancer on stroke risk factors, radiological and clinical features. Materials and Methods: Patients who were hospitalized with the diagnosis of stroke between 2014-2020 were included in the study retrospectively. By examining the stroke and cancer characteristics of the patients; The differences in demographic findings, stroke risk factors, and radiological features of stroke between patients with and without cancer were examined. The anti-cancer treatments used and the characteristics of cancer were evaluated in stroke patients. Results: 281 stroke patients were evaluated and cancer was detected in 52 patients. There was no significant difference in terms of demographic characteristics of the patients. No significant difference was observed in stroke patients with cancer in terms of risk factors except smoking and alcohol use. Multiple ischemic lesions were more evident on magnetic resonance imaging (MRI) in stroke patients with cancer. The most common cancer was lung cancer. Conclusion: Stroke and cancer are increasingly common comorbidities. As the time between stroke and cancer development decreases, while the risk factors for cancer are more prominent, classical risk factors for stroke are observed less frequently.

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  • 1. Wolf PA, D’Agostino RB, Belanger AJ, et al. Probability of stroke: a risk profile from the Framingham study. Stroke 1991;22:312-8.
  • 2. Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975-2008. Bethesda, MD: National Cancer Institute. Available at: http://seer.cancer.gov/ csr/ 1975_2008/. Accessed November 18, 2011
  • 3. Bethesda, MD: National Cancer Institute. Available at: http://seer.cancer.gov/csr/ 1975_2008/. Accessed November 18, 2011
  • 4. Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer. Medicine (Baltimore) 1985;64:16-35.
  • 5. Taccone FS, Jeangette SM, Blecic SA. First-ever stroke as initial presentation of systemic cancer. J Stroke Cerebrovasc Dis 2008;17:169-74.
  • 6. Adams HP Jr, Davis PH, Leira EC, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology 1999;53:126- 31.
  • 7. Cestari DM, Weine DM, Panageas KS, et al. Stroke in patients with cancer: incidence and etiology. Neurology 2004;62:2025-30.
  • 8. Levine SR. Hypercoagulable states and stroke: a selective review. CNS Spectrums 2005;10:567-578, Bick RL. Cancer-associated thrombosis. New Engl J Med 2003;349:109-11.
  • 9. Sanossian N, Djabiras C, Mack WJ, Ovbiagele B. Trends in cancer diagnoses among inpatients hospitalized with stroke. J Stroke Cerebrovasc Dis 2013;22:1146- 50.
  • 10. Kim SG, Hong JM, Kim HY, et al. Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea. Stroke 2010;41:798-801.
  • 11. Chaturvedi S, Ansell J, Recht L. Should cerebral ischemic events in cancer patients be considered a manifestation of hypercoagulability? Stroke 1994;25:1215-8.
  • 12. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006;4:2137
  • 13. Grisold W, Oberndorfer S, Struhal W. Stroke and cancer: a review. Acta Neurol Scand 2009;119:1-16.
  • 14. Zhang Y, Cordato D, Shen Q, et al. Risk factor, pattern, etiology and outcome in ischemic stroke patients with cancer: a nested case-control study. Cerebrovasc Dis 2007;23:181-7.
  • 15. Schwarzbach CJ, Schaefer A, Ebert A, Held V, Bolognese M, Kablau M, et al, Stroke and Cancer: The importance of Cancer-Associated Hypercoagulation as a Possible Stroke Aetiology. Stroke 2012;43:3029-34.
  • 16. Lee EJ, Nah HW, Kwon JY, Kang DW, Kwon SU, Kim JS. Ischaemic Stroke in patients with cancer: is it different from usual strokes? Int J Stroke 2014;9:406-12.
  • 17. Selvik HA, Thomassen L, Logallo N, Næss H. Prior cancer in patients with ischemic stroke: the Bergen NORSTROKE study. J Stroke Cerebrovasc Dis 2014;23:919-25.
  • 18. Stefan O, Vera N, Otto B, et al. Stroke in cancer patients: a risk factor analysis. J Neurooncol 2009;94:221-26.
  • 19. Navi BB, Singer S, Merkler AE, et al. Recurrent thromboembolic events after ischemic stroke in patients with cancer. Neurology 2014;83:26-33.
  • 20. Karlińska AG, Gromadzka G, Karliński MA, Członkowska A. The activity of malignancy may determine stroke pattern in cancer patients. J Stroke Cerebrovasc Dis. 2015;24:778-83.
  • 21. Lee AY, Levine MN. The thrombophilic state induced by therapeutic agents in the cancer patient. Semin Thromb Hemost 1999;25:137-45.
  • 22. Azoulay L, Yin H, Benayoun S, et al. Androgendeprivation therapy and the risk of stroke in patients with prostate cancer. Eur Urol 2011;60:1244-50
  • 23. Chu CN, Chen SW, Bai LY, et al. Increase in stroke risk in patients with head and neck cancer: a retrospective cohort study. Br J Cancer 2011;105:1419-23.
  • 24. Kim JM, Jung KH, Park KH, Lee ST, Chu K, Roh JK. Clinical manifestation of cancer related stroke: retrospective case-control study. J Neurooncol 2013;111:295-301.
  • 25. Borowski A, Ghodsizad A, Gams E: Stroke as a first manifestation of ovarian cancer. J Neurooncol 2005;71: 67-9
  • 26. Cornuz J, Bogousslavsky J, Schapira M, Regli F, Camenzind E: Ischemic stroke as the presenting manifestation of localized systemic cancer. Schweiz Arch Neurol Psychiatr 1988;139:5-11.
  • 27. Kwon MH: Stroke as the first manifestation of concealed cancer. J Neurol Sci 2007;258:80-3
  • 28. Dirix LY, Salgado R, Weytjens R, et al. Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer. Br J Cancer 2002;86:389- 95.
Annals of Medical Research-Cover
  • Yayın Aralığı: Aylık
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler

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