AyŞe Şahin TUTAK, Hüseyin Avni FINDIKLI, Abdulhamit Murat ERCİSLİ, Murat ARCAGÖK

Elevated platelet distribution width in peripheral artery disease

Aim: This study was planned with the hypothesis that atherosclerosis is in the etiology of peripheral artery disease (PAD), whethersymptomatic or not, and therefore thrombocyte-related parameters could show variability.Material and Methods: A retrospective examination was made of the laboratory records of 48 patients who presented at theCardiovascular Surgery Polyclinic with mild or severe symptoms and were diagnosed with PAD and a control group of 33 healthyindividuals.Results: No difference was determined between the patient and control groups in respect of age, gender, Platelet Count (Plt),C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), Mean Platelet Volume ( MPV), Hemoglobin (Hgb) and White BloodCells (WBC ) values. The Platelet distribution width (PDW) value of the patient group was found to be statistically significantlyhigher than that of the control group (p

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1. Simon F, Oberhuber A, Floros N, et al.Pathophysiology of chronic limb ischemia. Gefasschirurgie. 2018;23:13-18.
2. ESC Periferik atardamar hastalıklarının tanı ve tedavi kılavuzları-2012.
3. Collins R, Cranny G, Burch J, et al. A systematic review of duplex ultrasound, magnetic resonance angiography and computed tomography angiography for the diagnosis and assessment of symptomatic, lower limb peripheral arterial disease. Health Technol Assess 2007;11:1-184.
4. Koelemay MJ, den Hartog D, Prins MH, et al. Diagnosis of arterial disease of the lower extremities with duplex ultrasonography. Br J Surg 1996;83:404-9.
5. Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
6. Farias MG, Schunck EG, Dal Bó S, et al. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin Chem Lab Med 2010;48:255-7 . 7. Yilmaz H, Yilmaz G, Mentefle A, et al. Prognostic impact of platelet distribution width in patients with Crimean–Congo hemorrhagic fever. J Med Virol 2016;88:1862-6.
8. Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2011;58:2020-45.
9. Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clin Chem1997;43:1072-6.
10. Gao F, Chen C, Lyu J, et al. Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis. Neuropsychiatr Dis Treat. 2018;14:2233-9.
11. Bolayir A, Gokce SF. The role of mean platelet volume, platelet distribution width and platelet /lymphocyte ratio in development of cerebral venous thrombosis. Cumhuriyet Medical J 2017;39:683-91.
12. Golwala ZM, Shah H, Gupta N, et al. Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci 2016;16:356-62.
13. Zhang B, Gu J, Qiu Y, et al. Level of Platelet Distribution Width and Outcome Prediction in Patients with Traumatic Brain Injury. Clin Lab. 2017;63:1711-5.
14. Chen SY, Du J, Lu XN, et al. Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus. J Res Med Sci 2018;23:48.
15. de Gonzalo-Calvo D, de Luxán-Delgado B, RodríguezGonzález S, et al. Platelet distribution width is associated with 1-year all-cause mortality in the elderly population. J Clinical Gerontology and Geriatrics 2012;4:12-6.