Effects of high dose vitamin C administration in Covid-19 patients

Aim: There is currently no pharmacotherapy with for the treatment of COVID-19. We aimed to investigate the effects of early and high-dose vitamin C (VC) therapy in hospitalized patients with COVID-19. Materials and Methods: We included patients (n=139) who received high-dose VC supplement to the standard treatment protocol into group 1 (n=58), and only those who received a standard treatment protocol into group 2 (n=81). The patients' requirement for supplemental oxygen therapy, requirement for intensive care treatment and survival rates was investigated retrospectively. Furthermore, the changes in white blood cell, C-reactive protein (CRP), procalcitonin, D-Dimer, renal function tests, ferritin, and interleukin 6 values during hospitalization were evaluated. Results: When the groups were compared in terms of clinical data, there was no significant difference in terms of the patients requiring supplemental oxygen therapy (p=0.808), requiring intensive care (p=0.662), and survival rates (p=0.185). However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p

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1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62.
2. Surviving Sepsis campaign. Covid19-Ssc 2020. 2020;2019.
3. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel CoronavirusInfected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc 2020;323:1061-9.
4. Carr AC. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care 2020;24:1-2.
5. Fowler III AA, Kim C, Lepler L, et al. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World J Crit Care Med 2017;6:85.
6. Carr AC, Rosengrave PC, Bayer S, et al. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care 2017;21:1-10.
7. Bolignano D, Cernaro V, Gembillo G, et al. Antioxidant agents for delaying diabetic kidney disease progression : A systematic review and meta-analysis 2017;1-16.
8. Manuel R, Colunga L, Berrill M, et al. Quercetin and Vitamin C : An Experimental , Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease ( COVID-19 ) 2020;11:1-11.
9. Nabzdyk CS, Bittner EA. Vitamin C in the critically ill - indications and controversies. World J Crit Care Med 2018;7:52-61.
10. Review D. New Coronavirus ( 2019-nCoV / COVID-19 ) and Vitamin C Yeni Koronavirüs ( 2019-nCoV / COVID-19 ) ve Vitamin C 2020;40:2-6.
11. Hoang BX, Shaw G, Fang W, et al. Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection. J Glob Antimicrob Resist 2020;23:256-62.
12. COVID-19 (SARS-CoV-2 Infection) Guide. Republic Of Turkey Ministry Of Health, Directorate General Of Public Health. 2020;2 Nisan 2020:25.
13. Fowler AA, Truwit JD, Hite RD, et al. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients with Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA - J Am Med Assoc 2019;322:1261-70.
14. Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective BeforeAfter Study. Chest 2017;151:1229-38.
15. Teng J, Pourmand A, Mazer-Amirshahi M. Vitamin C: The next step in sepsis management? J Crit Care 2018;43:230-4.
16. Auer BL, Auer D, Rodgers AL. Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C. Eur J Clin Invest 1998;28:695-700.
17. Lamarche J, Nair R, Peguero A, et al. Vitamin C-Induced Oxalate Nephropathy. Int J Nephrol 2011;2011:1-4.
18. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506.