Canan Şule KARKINER, Ala ÜSTYOL, Hacer KAMALİ, Müge AYANOĞLU, Ahmet ÖZDEMİR, Demet CAN, Türkan GUNAY, İlker GUNAY, Döne DOĞAN, Tekin NACAROĞLU

Effect of industrialization on allergic diseases in school children

Aim: The lifestyle and environmental changes associated with industrialization and urbanization are crucial factors in determining the prevalence of allergic diseases.Material and Methods: The aim of this study was to determine the prevalence of asthma and other allergic disorders in an industrial town.Study Design: Prospective, Cross-sectional study. This cross-sectional population-based study was conducted in Kemalpasa, İzmir, Turkey, which is an industrial town. Using the International Study of Asthma and Allergies in Childhood (ISAAC), the questionnaire was carried out on 1511 school-children aged between 13-14 years living in the district center.Results: The ISAAC Phase One questionnaire was answered by 1373 (90.87%) students. Six hundred ninety two (50.5%) of the children were girls and 681 (49.5%) were boys. The frequency of ever wheezing was 34%,that of current wheezing was 31.1% and that of physician-diagnosed asthma was 4.1%. The frequency of ever rhinitis was 36.6%, current rhinitis was 31.3%, current allergic rhino-conjunctivitis was 22.1% and physician-diagnosed allergic rhinitis was 11.1%. The frequency of ever eczema was 11.3% and that of physician-diagnosed eczema was 3.6%.Conclusion: The prevalence of asthma was found to be significantly higher, although there was no significant difference in allergic rhinitis and eczema compared with non-industrial neighboring states. The incidence of asthma was higher than other provinces which may be explained by the risk factors associated with this industrialized area. The fact that only children of the same age group and residence were evaluated contributed to the epidemiological value of our study.

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Keeley DJ, Neill P, Gallivan S. Comparison of theprevalence of reversible airways obstruction in rural and urban Zimbabwe an children. Thorax 1991;46(8):549-53.
Thirty-one source has been reshaped as “Lai C. Asthma epidemiology in Asia-Pacific. Christchurch (NZ): Asthma Asia Forum. Auckland, New Zealand, 2002”.
Kim YK, Baek D, Koh YI, Cho SH, Choi IS, Min KU, et al. Outdoor air pollutants derived from industrial processes may be causally related to the development of asthma in children. Ann Allergy Asthma Immunol 2001;86(4):456-60.
Lin RS, Sung FC, Huang SL, Gou YL, Ko YC, Gou HW, et al. Role of urbanization and air pollution in adolescent asthma: a mass screening in Taiwan. J Formos Med Assoc 2001;100(10):649-55.
Shpakou A, Brożek G, Stryzhak A, Neviartovich T, Zejda J. Allergic diseases and respiratory symptoms in urban and rural children in Grodno Region (Belarus). Pediatr Allergy Immunol 2012;23(4):339-46.
Odhiambo JA, Ng’ang’a LW, Mungai MW, Gicheha CM, Nyamwaya JK, Karimi F, et al, Urban-rural differences in questionnaire-derived markers of asthma in Kenyan school children. Eur Respir J 1998;12(5):1105-12.
Bröms K, Norbäck D, Eriksson M, Sundelin C, Svärdsudd K. Effect of degree of urbanisation on age and sex-specific asthma prevalence in Swedish preschool children. BMC Public Health 2009;9:303.
Venn A, Lewis S, Cooper M, Hill J, Britton J. Questionnaire study of effect of sex and age on the prevalence of wheeze and asthma in adolescence. BMJ 1998;316(7149):1945-46.
Pearce N, Weiland S, Keil U, Langridge P, Anderson HR, Strachan D, et al. Self-reported prevalence of asthma symptoms in children in Australia, England, Germany and New Zealand: an international comparison using the ISAAC protocol. Eur Respir J 1993;6(10):1455-61.
Anderson HR, Ruggles R, Pandey KD, Kapetanakis V, Brunekreef B, Lai CK, et al. isaac phase one study group. ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: phase one of the international study of asthma and allergies in childhood (ISAAC).Occup Environ Med 2010;67(5):293-300.
Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S. International Study of Asthma and Allergies in Childhood Phase Three Study Group. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009;64(6):476-83.
Ripabelli G, Tamburro M, Sammarco ML, de Laurentiis G, Bianco A. Asthma prevalence and risk factors among children and adolescents living around an industrial area: a cross-sectional study. BMC Public Health 201313:1038.
Ones U, Akcay A, Tamay Z, Guler N, Zencir M. Rising trend of asthma prevalence among Turkish school children (ISAAC phases I and III). Allergy 2006;61(12):1448-53.
Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007;62(9):758-66.
Grize L, Gassner M, Wuthrich B, Bringolf-Isler B, Takken-Sahli K, Sennhauser FH, et al. Trends in prevalence of asthma, allergic rhinitis and atopic dermatitis in 5–7-year old Swiss children from 1992 to 2001. Allergy 2006;61(5):556-62.
Ronchetti R, Villa MP, Barreto M, Rota R, Pagani J, Martella S, et al. Is the increase in childhood asthma coming to an end? Findings from three surveys of schoolchildren in Rome, Italy. EurRespir J 2001;17(5):881-6.
Civelek E, Cakir B, Boz AB, Yuksel H, Orhan F, Uner A, et al. Extent and Burden of Allergic Diseases in Elementary Schoolchildren: A National Multicenter Study. J Investig Allergol Clin Immunol 2010;20(4):280-8.
Yuksel H, Dinc G, Sakar A, Yilmaz O, Yorgancioglu A, Celik P, et al. Prevalence and comorbidity of allergic eczema, rhinitis, and asthma in a city in western Turkey. J Investig Allergol Clin Immunol 2008;18(1):31-35.
Karaman O, Turgut CS, Uzuner N, Olmez D, Babayigit A, Kose S, et al. The determination of asthma, rhinitis, eczema, and atopy prevalence in 9- to 11-year-old children in the city of Izmir. Allergy Asthma Proc 2006;27(4):319-24.
Demir E, Tanaç R, Can D, Gülen F, Yenigün A, Aksakal K. Is there an increase in the prevalence of allergic diseases among schoolchildren from the Aegean region of Turkey? Allergy Asthma Proc 2005;26(5):410-4.
Saraçlar Y, Kuyucu S, Tuncer A, Sekerel B, Saçkesen C, Kocabaş C. Prevalence of asthmatic phenotypes and bronchial hyper responsiveness in Turkish school children: an International Study of Asthma and Allergies in Childhood (ISAAC) phase 2 study. Ann Allergy Asthma Immunol 2003;91(5):477-84.
Oneş U, Sapan N, Somer A, Dişçi R, Salman N, Güler N, et al. Prevalence of childhood asthma in Istanbul, Turkey. Allergy 1997;52(5):570-75.
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998;351(9111):1225-32.
Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8(3):483-91.
Shohat T, Golan G, Tamir R, Green MS, Livne I, Davidson Y, etal. Prevalence of asthma in 13-14 yr-old schoolchildren across Israel. Eur Respir J 2000;15(4):725-9.
Ige OM, Falade AG, Arinola OG. Atopy is a risk factor for adult asthma in urban community of Southwestern Nigeria. Lung India 2012;29(2):114-9.
Sestini P, De Sario M, Bugiani M, Bisanti L, Giannella G, Kaisermann D, et al. Frequency of asthma and allergies in Italian children and adolescents: results from SIDRIA-2. Epidemiol Prev 2005;29(2 Suppl):24-31.
Brunekreef B, Stewart AW, Anderson HR, Lai CK, Strachan DP, Pearce N. ISAAC Phase 3 Study Group. Self-reported truck traffic on the street of residence and symptoms of asthma and allergic disease: a global relationship in ISAAC phase 3. Environ Health Perspect 2009;117(11):1791-8.
Foliaki S, Pearce N, Björkstén B, Mallol J, Montefort S, von Mutius E. International Study of Asthma and Allergies in Childhood Phase III Study Group. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy ClinImmunol 2009;124(5):982-89.
Beasley R, Clayton T, Crane J, von Mutius E, Lai CK, Montefort S, et al. ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008;372(9643):1039-48.
Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368(9537):733-43.