Mehmet PATMANO, Alper AKCAN, Serap DOĞAN, İskender GÜN, Erdoğan SÖZÜER, Abdullah Bahadır ÖZ, Türkmen Bahadır ARIKAN

Comparison of surgery and surgery plus corticosteroid therapy in idiopathic granulomatous mastitis, prospective randomized study

Aim: To compare therapeutic effectiveness of surgery alone with surgery plus corticosteroid in patients with granulomatous mastitis.Material and Methods: The study included 30 patients aged 23-60 years. The patients were randomly assigned into two groupsby lot. In-group 1, the patients received 375 mg ampicillin-sulbactam (twice daily, p.o.) for a week; than 32 mg prednisolone wasstarted which was gradually tapered (biweekly by 8 mg) over 8 weeks. Surgery was performed 2 weeks after tapering. In-group 2,the patients received 375 mg ampicillin-sulbactam (twice daily, p.o.) for a week and underwent surgery. During 2-years follow-up, allpatients were assessed for etiological factors and recurrence.Results: No significant differences was found in demographic characteristics, smoking habits, oral contraceptive use, presentingcomplaints, physical examination findings, localization and diagnostic tools used between groups. During follow-up, recurrencewas seen in one patient (6.7%) in surgery group and in 3 patients (20%) in steroid group but no significant difference was detectedbetween groups (p>0.05).Conclusion: In patients with granulomatous mastitis, systemic steroid therapy is an effective modality in patients unresponsive toantibiotic therapy after ruling out tuberculosis.

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