Cardiovascular disease in type 2 diabetes mellitus: Relationship between microalbuminuria and cardiovascular risk factors
Cardiovascular disease in type 2 diabetes mellitus: Relationship between microalbuminuria and cardiovascular risk factors
Aim: In this study, the relationship between cardiovascular disease (CVD) risk factors and microalbuminuria (MAU) in patients with type 2 diabetes mellitus (DM) was investigated. Materials and Methods: The data of type 2 DM patients without CVD were evaluated retrospectively. Anthropometric measurements were made using calibrated standard devices. Biochemical data of the patients were obtained from the hospital information processing system. Patients with type 1 DM, history of CVD and diseases that may affect the MAU level were excluded from the study. Statistical analysis was done using SPSS 22.0. Results: The study included 300 type 2 DM patients with the mean age of 58.9±10.1. 56.7% of the cases (n=170) were female, and 43.3% (n=130) were male. 12.7% of the cases were obese (BMI>30 kg/m2 ). Body mass index, blood pressure (BP), LDL, glycated hemoglobin (HbA1c) and lipoprotein (a) levels were detected to be higher in patients with MAU (p
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- 1. DeFronzo RA. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004; 88:787-835.
- 2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37:81-90.
- 3. Pinchevsky Y, Butkow N, Raal FJ, et al. Demographic and clinical factors associated with development of type 2 diabetes: A review of the literature. Int J Gen Med 2020;13:121-9.
- 4. Singh GM, Danaei G, Farzadfar F, et al. The AgeSpecific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis. Wang G, editor. PLoS One. 2013;8:e65174.
- 5. Fox CS, Pencina MJ, Wilson PWF, et al. Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the framingham heart study. Diabetes Care 2008;31:1582- 4.
- 6. Tobe SW, McFarlane PA, Naimark DM. Microalbuminuria in diabetes mellitus. CMAJ 2002;167:499-503.
- 7. Kundu D, Roy A, Mandal T, et al. Relation of microalbuminuria to glycosylated hemoglobin and duration of type 2 diabetes. Niger J Clin Pract 2013;16:216.
- 8. Malik AR, Sultan S, Turner ST, Kullo IJ. Urinary albumin excretion is associated with impaired flow- and nitroglycerin-mediated brachial artery dilatation in hypertensive adults. J Hum Hypertens 2007;21:231-8.
- 9. Gross JL, De Azevedo MJ, Silveiro SP, et al. Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care 2005;28:164-76.
- 10. Imai E, Haneda M, Chan JCN, Y et al. Reduction and residual proteinuria are therapeutic targets in type 2 diabetes with overt nephropathy: A post hoc analysis (ORIENT-proteinuria). Nephrol Dial Transplant 2013;28:2526-34.
- 11. Turner RC. The U.K. Prospective Diabetes Study: A review. Diabetes Care 1998;C35-8.
- 12. Tapp RJ, Shaw JE, Zimmet PZ, B et al. Albuminuria is evident in the early stages of diabetes onset: Results from the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). Am J Kidney Dis 2004;44:792-8.
- 13. Meisinger C, Heier M, Landgraf R, et al. Albuminuria, cardiovascular risk factors and disease management in subjects with type 2 diabetes: A cross sectional study. BMC Health Serv Res 2008;8:1-7.
- 14. Afkhami-Ardekani M, Modarresi M, Amirchaghmaghi E. Prevalence of microalbuminuria and its risk factors in type 2 diabetic patients. Indian J Nephrol 2008;18:112.
- 15. Minoo F, Mahdavi-Mazdeh M, Abbasi M-R, Sohrabi S. Impact of the severity of obesity on microalbuminuria in obese normotensive nondiabetic individuals. J Ren Inj Prev 2015;4:34-8.
- 16. Verdecchia P, Reboldi GP. Hypertension and microalbuminuria: The new detrimental duo. Blood Pressure 2004;13:198-211.
- 17. Bavikar P, Kusalkar S, Ghanekar J. Study of Microalbuminuria in patients with Hypertension. 2018;6:756-60.
- 18. Ozturk MT, Ebinc FA, Okyay GU, Kutlugun AA. Epicardial adiposity is associated with microalbuminuria in patients with essential hypertension. Acta Cardiol Sin 2017;33:74-80.
- 19. Kang DH, Nakagawa T, Feng L, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002;13:2888-97.
- 20. Kosugi T, Nakayama T, Heinig M, et al. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol - Ren Physiol 2009;297:481-8.
- 21. Latif H, Iqbal A, Rathore R, Butt NF. Correlation between Serum Uric Acid Level and Microalbuminuria in Type-2 Diabetic Nephropathy. Pakistan J Med Sci 2017;33:1371.
- 22. Fukui M, Tanaka M, Shiraishi E, et al. Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes mellitus. Metabolism 2008;57:625-9.
- 23. Kawanami D, Matoba K, Utsunomiya K. Dyslipidemia in diabetic nephropathy. Renal Replacement Therapy 2016;2:1-9.
- 24. Wassef L, Langham R, Kelly D. Vasoactive Renal Factors and the Progression of Diabetic Nephropathy. Curr Pharm Des 2005;10:3373-84.
- 25. Tseng CH. Lipid abnormalities associated with urinary albumin excretion rate in Taiwanese type 2 diabetic patients. Kidney Int 2005;67:1547-53.
- 26. Gencer B, Kronenberg F, Stroes ES, Mach F. Lipoprotein(a): the revenant. Eur Heart J 2017;38(20):1553-60.
- 27. Kronenberg F. Causes and consequences of lipoprotein(a) abnormalities in kidney disease. Clin Exp Nephrol 2014;18:234-7.
- 28. Senba H, Furukawa S, Sakai T, et al. Serum lipoprotein(a) levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus. J Diabetes Complications 2016;30:923-7.
- 29. Yun J-S, Ahn Y-B, Song K-H, et al. Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus. Diabet Med 2016;33:639-43.
- 30. Goyal B, Goyal J, Sinha M, et al. Association of glycosylated hemoglobin with microalbuminuria in patients with type 2 diabetes mellitus. International Journal of Biotechnology and Biochemistry 2017;13:311-23.
- 31. Kundu D, Roy A, Mandal T, et al. Relation of microalbuminuria to glycosylated hemoglobin and duration of type 2 diabetes. Niger J Clin Pract 2013;16:216.
- 32. Memon MY, Mughal MA, Memon SH, et al. Correlation of Microalbuminuria with Glycated Hemoglobin, Blood Pressure and Duration of Diabetes. J Diabetes Res Endocrinol 2017;1:1-7.
- 33. De Boer IH, Rue TC, Cleary PA, et al. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: An analysis of the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort. Arch Intern Med 2011;171:412-20.