Can neutrophil-lymphocyte ratio be a predictor of lateonset sepsis in preterm infants?

Can neutrophil-lymphocyte ratio be a predictor of lateonset sepsis in preterm infants?

Aim: Late-onset sepsis (LOS) persists to be a crucial reason of morbidity and mortality in preterm infants. Studying the effect ofneutrophil-lymphocyte ratio (NLR) value in predicting the LOS episode and relation with the type of the growing microorganism werethe aim of this study.Material and Methods: Preterm infants were classified as two groups in accordance with having culture proven LOS during the stayin neonatal intensive care unit. Premature infants with culture proven LOS was defined as study group and infants with no-LOS ascontrol group. Study group is consisting of two subgroups in terms of the growing microorganism type. NLR values were comparedwithin and between the groups.Results: Overall, final analysis were applied to 116 infants. NLR values were raised in the study group during LOS episode (p

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  • 1. Bekhof J, Reitsma JB, Kok JH et al. Clinical signs to identify late-onset sepsis in preterm infants. Eur J Pediatr. 2013;172:501-8.
  • 2. Satar M, Arisoy AE, Celik IH. Turkish Neonatal Society guideline on neonatal infections-diagnosis and treatment. Turk Pediatri Ars 2018;53(Suppl 1):88-100.
  • 3. Dong Y, Speer CP. Late-onset neonatal sepsis: recent developments. Arch Dis Child Fetal Neonatal Ed 2015;100:F257-63.
  • 4. Shane AL, Sanchez PJ, Stoll BJ. Neonatal sepsis. Lancet. 2017;390(10104):1770-80.
  • 5. Pammi M, Weisman LE. Late-onset sepsis in preterm infants: update on strategies for therapy and prevention. Expert Rev Anti Infect Ther. 2015;13:487- 504.
  • 6. Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010;37:421-38.
  • 7. Omran A, Maaroof A, Saleh MH, et al. Salivary C-reactive protein, mean platelet volume and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. J Pediatr (Rio J) 2018;94:82-7.
  • 8. Can E, Hamilcikan S, Can C. The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. J Pediatr Hematol Oncol 2018;40:e229-e32.
  • 9. Temel MT, Coskun ME, Akbayram S, et al. Association between neutrophil/lymphocyte ratio with ductus arteriosus patency in preterm newborns. Bratisl Lek Listy 2017;118:491-4.
  • 10. Kurtul BE, Kabatas EU, Zenciroglu A, et al. Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity. J AAPOS 2015;19:327-31.
  • 11. Raimondi F, Ferrara T, Maffucci R, et al. Neonatal sepsis: a difficult diagnostic challenge. Clin Biochem 2011;44:463-4.
  • 12. Paolucci M, Landini MP, Sambri V. How can the microbiologist help in diagnosing neonatal sepsis? Int J Pediatr 2012;2012:120139.
  • 13. Chauhan N, Tiwari S, Jain U. Potential biomarkers for effective screening of neonatal sepsis infections: An overview. Microb Pathog 2017;107:234-42.
  • 14. Mussap M, Noto A, Cibecchini F, et al. The importance of biomarkers in neonatology. Semin Fetal Neonatal Med 2013;18:56-64.
  • 15. Liu X, Shen Y, Wang H, et al. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study. Mediators Inflamm 2016;2016:8191254.
  • 16. Hwang SY, Shin TG, Jo IJ, et al. Neutrophil-tolymphocyte ratio as a prognostic marker in criticallyill septic patients. Am J Emerg Med 2017;35:234-9.
  • 17. Ljungstrom L, Pernestig AK, Jacobsson G, et al. Diagnostic accuracy of procalcitonin, neutrophillymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis. PLoS One 2017;12:e0181704.
  • 18. Meshaal MS, Nagi A, Eldamaty A, et al. Neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as independent predictors of outcome in infective endocarditis (IE). Egypt Heart J 2019;71:13.
  • 19. Kaplan M, Ates I, Oztas E, et al. A New Marker to Determine Prognosis of Acute Pancreatitis: PLR and NLR Combination. J Med Biochem 2018;37:21-30.
  • 20. Tumturk A, Ozdemir MA, Per H, et al. Pediatric central nervous system tumors in the first 3 years of life: pre-operative mean platelet volume, neutrophil/ lymphocyte count ratio, and white blood cell count correlate with the presence of a central nervous system tumor. Childs Nerv Syst 2017;33:233-8.
  • 21. Karabulut B, Arcagok BC, Simsek A. Utility of the Platelet-to-Lymphocyte Ratio in Diagnosing and Predicting Treatment Success in Preterm Neonates with Patent Ductus Arteriosus. Fetal Pediatr Pathol 2019:1-10.
  • 22. Alkan Ozdemir S, Arun Ozer E, Ilhan O, et al. Can neutrophil to lymphocyte ratio predict lateonset sepsis in preterm infants? J Clin Lab Anal 2018;32:e22338.
  • 23. Sarkar S, Bhagat I, Hieber S, et al. Can neutrophil responses in very low birth weight infants predict the organisms responsible for late-onset bacterial or fungal sepsis? J Perinatol 2006;26:501-5.
Annals of Medical Research-Cover
  • Yayın Aralığı: 12
  • Yayıncı: İnönü Üniversitesi Tıp Fakültesi
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