Mustafa Yavuz GÜLBAHAR, Sinem İNAL, Edward Bealmear BREITSCHWERDT, Nandhakumar BALAKRISHNAN, Ishtiaq AHMED, Alper ÇİFTCİ, Efe KARACA

Türkiye’de bir kedide Bartonella henselae ile ilişkili pyogranülomatöz miyokarditis ve diyaframatik myozitis

Bu çalışmada Türkiye’de 18 aylık üç renkli dişi bir kedide Bartonella henselae’ya bağlı pyogranülomatöz myocarditis ve diyaframatik myositis rapor edilmiştir. Klinik olarak hastalık oluşmadan önce kedide pire enfestasyonu vardı. Kedide durgunluk, iştahsızlık, solunum güçlüğü, aşırı salivasyon ve aşırı su içme isteği semptomları görüldü. Nekropside miyokardda çok sayıda, ayrı ya da birleşme eğilimi gösteren 1-2 mm çapında beyaz-gri nodüller ile göğüs boşluğunda 250 ml serö-sanguinöz yapıda sıvıya rastlandı. Miyokardiyal ve diyaframatik lezyonlarda Warthin-Starry boyama ile argirofilik pleomorfik kokobasiller görülmüştür. Kalp, böbrek ve karaciğer dokularında riboflavin sentaz C (RibC) gen hedefleyen PCR ile B. henselae DNA’sı belirlendi. İmmunofloresan teknik ile de myokardiyumda B. henselae gösterildi. Bu rapor kedilerde pyogranülomatöz myokarditis, diaframatik myozitis ve B. henselae enfeksiyonu arasındaki etiyolojik ilişkiyi destekleyen ilave bir kanıt sağlamaktadır.

Pyogranulomatous myocarditis and diaphragmatic myositis associated with Bartonella henselae in a cat from Turkey

A case of pyogranulomatous myocarditis and diaphragmatic myositis caused by Bartonella henselae in an 18 months old tricolor female cat in Turkey was reported in this study. The cat had flea infestation before clinical disease onset. The cat showed clinical findings including lethargy, anorexia, dyspnea, hypersalivation, and polydipsia. At necropsy, the myocardium contained numerous 1 to 2 mm, discrete to coalescing, white-grey nodular foci with approximately 250 ml of serosanguineous fluid in the thorax. By Warthin-Starry silver staining, argyrophilic pleomorphic coccobacilli were seen within the myocardial and diaphragmatic pyogranulomatous lesions. B. henselae DNA was detected in heart, kidney and liver tissues by targeting the riboflavin synthase C (ribC) gene by PCR. Using immunofluorescence technique, B. henselae was also visualized in myocardial tissues. This report provides additional evidence in support of an etiological association between pyogranulomatous myocarditis and diaphragmatic myositis and B. henselae infection in cats.

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