Tedaviye Dirençli Hipotiroidi

Hipotiroidi toplumda sık görülen bir problemdir. Hipotiroidinin standart tedavisi sentetik L-tiroksin (L-T4) sodyum preparatları ile replasmandır. Tedavide hedef TSH’ yı normal referans değerleri arasında tutmaktır. Beklenen dozların üzerinde L-T4 gereksinimi olan hastalarda altta yatan nedeni tespit etmek zor olabilir. Bu hastalarda öncelikli olarak ilaç alımında uyumsuzluk düşünülmeli ve sonra da altta yatan biyolojik bir neden olup olmadığı da araştırılmalıdır.

Therapy Resistant Hypothyroidism

Hypothyroidism is a common problem in the population. Standard therapy for hypothyroidism is the replacement with synthetic L-thyroxine (L-T4) sodium preparations. The target of the treatment is to maintain TSH levels between normal reference values. Detection of the underlying reason can be difficult in patients with higher L-T4 dose requirement than expected. In these patients, primarily non-adherence to the therapy should be remembered and then, whether there is an underlying reason or not should be investigated.

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